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Galya Monderer-Rothkoff on Muck Rack

Galya Monderer-Rothkoff

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Articles

AUTS2 isoforms control neuronal differentiation

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By Odem Shani, Galya Monderer-Rothkoff, Nitzan Tal, Marina Risman
| Nature Verified
Abstract Mutations in AUTS2 are associated with autism, intellectual disability, and microcephaly. AUTS2 is expressed in the brain and interacts with polycomb proteins, yet it is still unclear how mutations in AUTS2 lead to neurodevelopmental phenotypes. Here we report that when neuronal differentiation is initiated, there is a shift in expression from a long isoform to a short AUTS2 isoform.
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