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Ganesh Kumar Barik on Muck Rack

Ganesh Kumar Barik

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

Apoptosis‐Inducing Activity of a 2‐Hydroxyphenyl Benzamide‐Based Self‐Assembled Anion Channel

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By Abhishek N. Mondal, Ganesh Kumar Barik, Susmita Sarkar, Umesh Shivpuje
| Wiley Online Library Verified
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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Loss of FBXO31-mediated γH2AX foci formation impairs initiation of NHEJ and HR repair pathways, and sensitizes breast cancer to therapy

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By Osheen Sahay, Ganesh Kumar Barik, Sehbanul Islam, Samya Dey
| BioRxiv
Abstract In response to genotoxic stress, cell initiates complex signalling cascades to combat genomic insults through simultaneous initiation of growth arrest and DNA damage repair process. γH2AX functions as a crucial initiator in DNA double strand damage repair process. Therefore, γH2AX foci formation onto the damage sites is essential to initiate the recruitment of repair proteins involved in NHEJ (Non-homologous DNA-end joining) or HR (Homologous recombination) repair process.
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FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis - Cell Death & Disease

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By Sehbanul Islam, Ganesh Kumar Barik
| Nature Verified
Abstract Oncogene Moesin plays critical role in initiation, progression, and metastasis of multiple cancers. It exerts oncogenic activity due to its high-level expression as well as posttranslational modification in cancer. However, factors responsible for its high-level expression remain elusive. In this study, we identified positive as well as negative regulators of Moesin. Our study reveals that Moesin is a cellular target of F-box protein FBXW2.
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