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Articles

Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences

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By Gant TW, Garcia-Reyero N, Helm JS, Danielsen PH
| ncbi.nlm.nih.gov
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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity

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By von Bergen M, Gant TW, Auerbach SS, Botham PA
| ncbi.nlm.nih.gov
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Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment - PubMed

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By Gant TW, van Ravenzwaay B, Kramer NI
| ncbi.nlm.nih.gov
With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of in vitro assay readouts for quantitative hazard characterisation becomes more important. Physiologically based kinetic (PBK) models, which simulate the fate of chemicals in tissues of the body, play an essential role in extrapolating in vitro effect concentrations to in vivo bioequivalent exposures.
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