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Gaochao Zhang on Muck Rack

Gaochao Zhang

Beijing
As seen in: Los Angeles Times, Science Magazine, Orlando Sentinel
News Researcher@LATimes Beijing Bureau Independent Sport Commentator Broadcaster
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Articles

ATRA improves megakaryopoiesis in immune thrombocytopenia through up-regulating the HIF-1α/SPHK2/S1P pathway

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By Valdemar Priebe, Peter Sheridan Dodds, Mohammad A Saad, Qiu-Sha Huang, Jing XUE, Feng-Qi Liu, Qi Chen, Gaochao Zhang, Xue-yan Sun, Chencong Wang, Liping Yang, Yu Hou, Yueying Li, Qianfei Wang, Jun Peng, Ming Hai Hou, Xiaosu Zhao, Yuan Kong, Yingjun Chang, Xiangyu Zhao, Xiao-Jun Huang, Xiao-Hui Zhang
| Science Magazine Verified
Abstract Our previous clinical studies show that all-trans retinoic acid (ATRA) induces a sustained response in patients with immune thrombocytopenia (ITP). However, its mechanisms of action remain unclear. In this study, we observed disorganized cytoskeleton and impaired proplatelet formation (PPF) in megakaryocytes from patients with ITP. Metabolite profiling revealed reduced sphingosine 1-phosphate (S1P) levels in ITP.
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'Avengers: Infinity War' becomes top-grossing Marvel movie in China

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By Gaochao Zhang
| Orlando Sentinel Verified
“Avengers: Infinity War” soared to the top of China’s box office last weekend, becoming the highest-grossing Marvel film in the Middle Kingdom and the fourth most-successful Hollywood import of all time. Underscoring the appeal of superhero movies in China, the film pulled in $102 million in box office receipts for a total of $300.6 million after 10 days, according to film consulting firm Artisan Gateway. The action film was helped by strong audience reviews.
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