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Trans-cuff budesonide delivery and its effects on endotracheal intubation-induced subglottic injury
Abstract Objectives: This study aimed to determine whether budesonide inhalation suspension (BIS) diffuses through polyvinyl chloride (PVC) endotracheal tube (ETT) cuffs and whether intracuff budesonide attenuates the acute subglottic injury during endotracheal intubation (ETI) in a rabbit model. Methods: in vitro, high-performance liquid chromatography was used to quantify trans-cuff diffusion of budesonide from 2.5-mm-ID PVC ETT cuffs.
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