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Signal transduction by the IL-36 receptor (IL-36R) is linked to several human diseases. However, the structure and function of the IL-36R is not well understood. A molecular model of the IL-36R complex was generated and a cell-based reporter assay was established to assess the signal transduction of recombinant subunits of the IL-36R.
Author contributions: CC.C.K. and M.L.M. conceived and coordinated the study, analyzed all results and wrote the paper. G.Y. acquired the results in Fig. 1A, 2B-2E, 3A, 3C, 4A-4F, 5A-5C, 5E, 6B-D, 7A-7D, 7F, 8C, 8D and 9A-D and 9E, 9F, analyzed the results, and wrote the paper.J.Y. acquired the models in Fig. 1B-1D, 3B, 5D, 6A, 8A-B, 9E and contributed to the writing. S. S. acquired the results in Fig. 2A, 2F, 7E and helped analyzed the results.
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