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Gary KL Chan on Muck Rack

Gary KL Chan

As seen in: eLife
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Articles

The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures

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By Hans Clevers, Ibrahim Ahmed, Gary KL Chan, Antonella FM Dost
| eLife
The vast majority of LC cases are attributable to the effects of smoking and air pollution. The repetitive tissue damage caused by tobacco inhalation leads to high levels of immune cell infiltration, causing widespread tumor-promoting inflammation. Smoking also induces specific mutations within the lung epithelium, which can then generate a large number of neoantigens (Schumacher and Schreiber, 2015; Alexandrov et al., 2013).
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Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms

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By Gary KL Chan, Samantha Maisel, Yeonjoo C Hwang, Bryan C Pascual
| eLife
Abstract Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood. We used global phosphoproteomics and kinase activity profiling to map conserved signaling outputs driven by a range of genetic changes that activate PKA in human cancer.
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