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Articles by Gary Wu
Early-life colonization with Clostridioides difficile remodels the developing gut
Editor’s summary Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Editor’s summary Clostridioides difficile bacteria are common in the human gut microbiome and can expand to cause severe opportunistic infections. When babies are colonized early in life, they are generally asymptomatic for C. difficile disease. Semon et al.
Fermented food microbiome: influence on oral and gut microbiota, and human health
Abstract The fermented food microbiome comprises live microorganisms, their genetic elements and their metabolites, and represents an established dietary approach for modulating host–microbiome interactions through the consumption of fermented foods. Fermentation enhances food preservation and nutrient bioavailability, and supplies the host with probiotics, prebiotic substrates and postbiotic metabolites.
Glucuronidation metabolomic fingerprinting to map host-microbe metabolism
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Abstract Glucuronidation is an important detoxification pathway that operates in balance with gastrointestinal microbial β-glucuronidase (GUS) activity, which can regenerate bioactive metabolites from their glucuronidated forms. How this host-microbe interaction shapes the distribution and pool of glucuronidated metabolites (i.e., the glucuronidome) remains poorly understood.
By Josh J. Sekela, Mingxun Wang, Helena Mannochio-Russo, Jeong Pyo, Min Kim, Shuchang Tian, Imhoi Koo, Elliot S. Friedman, Ceylan Tanes, Mallappa Anitha, Yuan Tian, Ethan Morgan, Iain Murray, Joseph P. Zackular, Kyle Bittinger, James Lewis, Gary H. Perdew, Gary Wu, Babette S. Zemel, Pieter C. Dorrestein, Jordan E Bisanz, Matthew R. Redinbo, Andrew Patterson, Nina R. Boyle
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Nature
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Also available on ScienceDirect
Is A Patent Right Evaluation Report Necessary For Asserting Utility Model And Design Patent Rights In China?
In the field of intellectual property agency work, it is not uncommon for patent holders, especially foreign patent holders, to be puzzled by a seemingly counterintuitive requirement. Despite having obtained authorization for their utility model patents or design patents from the Chinese Patent Office, they are often required to provide a Patent Right Evaluation Report when seeking to enforce these patents against infringers. Why is this additional step necessary?
In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier
Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Is A Patent Right Evaluation Report Necessary For Enforcing Utility Model And Design Patents In China?
In intellectual property agency practice, patent holders often entrust our law firm to enforce their authorized utility model and design patents in China to combat infringement by unauthorized parties.
An Open-Label Case Series of Glutathione Use for Symptomatic Management in Children with Autism Spectrum Disorder
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Development of the Penn Healthy Diet screener with reference to adult dietary intake data from the National Health and Nutrition Examination Survey - Nutrition Journal
Dietary patterns have been linked to many of the most common causes of morbidity and mortality in the modern world, such as metabolic syndrome, diabetes mellitus, cardiovascular disease, and cancer [1]. Metabolic syndrome is characterized by abdominal adiposity, dyslipidemia, hypertension, and insulin resistance, and is associated with cardiovascular disease, diabetes mellitus and cancer [2, 3].
Response to: Olesen SW, “Fecal microbiota transplantation “donor effects” are not clinically relevant for Clostridioides difficile infection.”
This paper is only available as a PDF. To read, Please Download here.
Impact of clinical decision support on oritavancin prescribing in the emergency department
This paper is only available as a PDF. To read, Please Download here. Abstract Background: Emergency department (ED) visits and hospitalization from skin and soft tissue infections (SSTIs) has been on the rise and has led to increased clinical and economic burden. Due to its single-dose regimen, recently approved lipoglycopeptides such as oritavancin has potential to shift management of SSTIs from an inpatient to outpatient setting. Limited data exists regarding use of these drugs in the ED setting.
Patents Comparative Guide - Intellectual Property - China
To print this article, all you need is to be registered or login on Mondaq.com. Do you want to compare other jurisdictions?... Click here 1 Legal framework 1.1 What are the sources of patent law in your jurisdiction? The Chinese patent regime aims to: protect inventions; encourage innovation; promote the dissemination and application of inventions; and promote the development of science and technology, to meet the needs of socialist modernisation.
MONITORING FECAL MICROBIOTA TRANSPLANTATION PRACTICE IN A RAPIDLY EVOLVING HEALTH AND REGULATORY ENVIRONMENT
Colleen R. Kelly, MD Colleen R. Kelly Correspondence Corresponding Author Colleen R. Kelly 146 W River St. Suite 1H Providence, RI 02904 (401) 793-7080 Affiliations Warren Alpert Medical School of Brown University, Miriam Hospital, and Lifespan Hospital System, Providence, Rhode Island Search for articles by this author Loren A. Laine, MD, AGAF Gary D. Wu, MD This paper is only available as a PDF. To read, Please Download here. Key Words FMT Safety Registry C.
Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production
Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production Free Gary D Wu1, Charlene Compher2, Eric Z Chen3, Sarah A Smith1, Rachana D Shah4, Kyle Bittinger5, Christel Chehoud5, Lindsey G Albenberg6, Lisa Nessel3, Erin Gilroy3, Julie Star1, Aalim M Weljie7, Harry J Flint8, David C Metz1, Michael J Bennett9, Hongzhe Li3, http://orcid.org/0000-0003-4740-4056Frederic D Bushman5, James D Lewis1,3 1Division of Gastroenterology,...
Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes
We coexist with our gut microbiota as mutualists, but this relationship sometimes becomes pathological, as in obesity, diabetes, atherosclerosis, and inflammatory bowel diseases (1, 2). Factors including age, genetics, and diet may influence microbiome composition (3). Of these, diet is easiest to modify and presents the simplest route for therapeutic intervention.
Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice
Gammaherpesviruses encode proteins with homology to the cellular purine metabolic enzyme formyl-glycinamide-phosphoribosyl-amidotransferase (FGARAT), but the role of these viral FGARATs (vFGARATs) in the pathogenesis of a natural host has not been investigated. We report a novel role for the ORF75A vFGARAT of murine gammaherpesvirus 68 (MHV68) in infectious virion production and colonization of mice.
Gut microbiota and IBD: causation or correlation?
Key Points Alterations in intestinal microbial composition have long been associated with chronic inflammation; however, a definitive cause–effect relationship between dysbiosis and IBD has been difficult to prove, especially in humans Dysbiosis alters not only the composition of the intestinal microbiota, but also its metabolome, thereby exerting a wide range of effects on the host While the microbiota plays a key pathogenic role in IBD, chronic inflammation, in turn, promotes dysbiosis by...
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