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Pieter C. Dorrestein on Muck Rack

Pieter C. Dorrestein

San Diego
As seen in: Nature, Science Magazine, Royal Society of Chemistry, BioRxiv, Cell Press, Gastroenterology, The Analytical Scientist
I enjoy chemical analysis by mass spectrometry associated with microbes, microbiome, forensics, agriculture, drug discovery and metabolism.
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Articles

Multi-omics analyses of facial skin in acne identify distinct microbial and metabolic features at lesional and non-lesional sites

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By Yang Chen, Britta De Pessemier, Tyler Myers, Simone Zuffa, Jasmine Zemlin, Magali Moreau, Jolanta Idkowiak-Baldys, Chloe Lieng, Samia Almoughrabie, Anna Nguyen, Josh L. Espinoza, Christopher L. Dupont, Chris Callewaert, Daniel McDonald, Daniel Mcdonald, Karsten Zengler, Andrew Bartko, Philippe Barbarat, Richard L. Gallo, Pieter C. Dorrestein, Qian Zheng, Amina Bouslimani, Rob Knight Verified, Sayeh Pourhamidi, Iveta Kalcheva, Tom Van de Wiele, Luc Aguilar
| Nature Verified
Abstract The microbial and biochemical landscape of clinically normal-appearing skin in individuals with acne remains uncharacterized. Here, we performed longitudinal multi-omics profiling of facial skin from 10 moderate acne patients and 10 healthy controls, integrating 16S rRNA gene sequencing, shotgun metagenomics, and untargeted metabolomics across lesional and non-lesional sites.
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Bridging complexity and accessibility in metabolomics with MetaboApps

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By Helena Mannochio-Russo, Haoqi Zhao, Kine Eide Kvitne, Shipei Xing, Harsha Gouda, Julius Agongo, Ipsita Mohanty, Vincent Charron-Lamoureux, Prajit Rajkumar, Abzer K. Pakkir Shah, Axel Walter, Yasin El Abiead, Patrick Ferreira, Simone Zuffa, Abubaker Patan, Andrés Mauricio Caraballo-Rodríguez, Wout Bittremieux, Daniel Petras, Mingxun Wang, Pieter C. Dorrestein, Wilhan D. Gonçalves Nunes, Rithi Krishnaraj
| Nature Verified
Untargeted metabolomics is a powerful approach for exploring the chemical diversity and dynamics of biological systems. However, the types of questions that can be addressed depend not only on experimental design but also on the data processing and analysis workflows used, many of which require advanced computational expertise.
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Glucuronidation metabolomic fingerprinting to map host-microbe metabolism

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By Josh J. Sekela, Mingxun Wang, Helena Mannochio-Russo, Jeong Pyo, Min Kim, Shuchang Tian, Imhoi Koo, Elliot S. Friedman, Ceylan Tanes, Mallappa Anitha, Yuan Tian, Ethan Morgan, Iain Murray, Joseph P. Zackular, Kyle Bittinger, James Lewis, Gary H. Perdew, Gary Wu, Babette S. Zemel, Pieter C. Dorrestein, Jordan E Bisanz, Matthew R. Redinbo, Andrew Patterson, Nina R. Boyle
| Nature Verified
Abstract Glucuronidation is an important detoxification pathway that operates in balance with gastrointestinal microbial β-glucuronidase (GUS) activity, which can regenerate bioactive metabolites from their glucuronidated forms. How this host-microbe interaction shapes the distribution and pool of glucuronidated metabolites (i.e., the glucuronidome) remains poorly understood.
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