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A common pathway controls cell size in the sepal and leaf epidermis leading to a nonrandom pattern of giant cells
Citation: Clark FK, Weissbart G, Wang X, Harline K, Li C-B, Formosa-Jordan P, et al. (2025) A common pathway controls cell size in the sepal and leaf epidermis leading to a nonrandom pattern of giant cells. PLoS Biol 23(11): e3003469. https://doi.org/10.1371/journal.pbio.3003469 Academic Editor: Mark Estelle, University of California San Diego, UNITED STATES OF AMERICA Received: November 2, 2024; Accepted: October 16, 2025; Published: November 3, 2025 Copyright: © 2025 Clark et al.
A common pathway controls cell size in the sepal and leaf epidermis leading to a non-random pattern of giant cells
Abstract Arabidopsis leaf epidermal cells have a wide range of sizes and ploidies, but how large cells are spatially patterned alongside smaller cells remains unclear. Here, we demonstrate that the same genetic pathway that creates giant cells in sepals is also responsible for their formation in the leaf epidermis. In both sepals and leaves, giant cells are scattered among smaller cells; therefore, we asked whether the spatial arrangement of giant cells is random.
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