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Administrative Burden of iPLEDGE Deters Isotretinoin Prescriptions: Results From a Survey of Dermatologists
Isotretinoin is the most effective treatment of recalcitrant acne, but because of its teratogenicity and potential association with psychiatric adverse effects, it has been heavily regulated by the US Food and Drug Administration (FDA) through the iPLEDGE program since 2006.1,2 To manage the risk of teratogenicity associated with isotretinoin, various pregnancy prevention programs have been developed, but none of these programs have demonstrated a zero fetal exposure rate.
Locally recurrent primary cutaneous coccidioidomycosis
Key words Coccidioides immitis Coccidioides posadasii immunosuppression PCC primary cutaneous coccidioidomycosis valley fever Abbreviation used: PCC (primary cutaneous coccidioidomycosis) Introduction Coccidioidomycosis is a highly infectious mycosis endemic to the southwestern and western United States and northern areas of Mexico. It is caused by 2 dimorphic species, Coccidioides immitis and Coccidioides posadasii. , 2 Russell D.H. Ager E. Wohltman W.
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