Gehan Labib Abuelenain on Muck Rack

Gehan Labib Abuelenain

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Runx3 Acts as Homodimeric Chromatin Binding Factor Regulating Heterochromatin-Mediated Cancerous Phenotype

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By Salma Mahmoud, Isabelle Bonne, Aik Yong Sim, Gehan Labib Abuelenain
| biorxiv.org
Abstract The recent paradoxical dual citizenships of Runt-related transcription factor 3 (Runx3) in tumorigenesis remains poorly characterized. Here, we report the oncogenic capacity of Runx3 as chromatin modulator in metastatic gastric cancer model. Runx3 exists as homodimer and binds cooperatively to modified nucleosomes. Additionally, we detected a synergistic functional enhancement of octamer transfer, nucleosome sliding and stochiometric integrity of SWI/SNF by Runx3.
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