Gejing De on Muck Rack

Gejing De

As seen in: Future Medicine
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Articles

hURAT1 Transgenic Mouse Model for Evaluating Targeted Urate-Lowering Agents

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By Gejing De, Qinghe Zhao, Weiyan Cai, Miyi Yang
| biorxiv.org
Abstract Objective: Urate transporter 1 (URAT1), a well-established urate-lowering therapeutic target for hyperuricemia and gout treatment, expresses in the kidney proximal tubule and is responsible for uric acid (UA) reabsorption.
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Inhibition of breast cancer metastasis by paclitaxel-loaded pH responsive poly(β-amino ester) copolymer micelles

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By Yanjun Chen, Jie Wang, Qiaoxin Yue, Gejing De
| Future Medicine Verified
Aim: Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly(?-amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis. Materials & methods: PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice.
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