Genís Valentín Gesé on Muck Rack

Genís Valentín Gesé

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Articles

Structural basis of 3′-tRNA maturation by the human mitochondrial RNAse Z complex

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By Genís Valentín Gesé, B. Hallberg
| biorxiv.org
Abstract Human mitochondrial tRNA maturation is essential for cellular energy production, yet the underlying mechanisms remain only partially understood. Here, we present several cryo-EM structures of the mitochondrial RNase Z complex (ELAC2/SDR5C1/TRMT10C) bound to different maturation states of mitochondrial tRNA(His), showing the molecular basis for tRNA-substrate selection and catalysis.
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Structural basis for late maturation steps of the human mitoribosomal large subunit

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By Miriam Cipullo, B. Hallberg, Genís Valentín Gesé, Anas Khawaja
| Nature Verified
Abstract Mitochondrial ribosomes (mitoribosomes) synthesize a critical set of proteins essential for oxidative phosphorylation. Therefore, mitoribosomal function is vital to the cellular energy supply. Mitoribosome biogenesis follows distinct molecular pathways that remain poorly understood.
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