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Genoveffa Franchini on Muck Rack

Genoveffa Franchini

As seen in: Nature, Science Magazine, Dialnet - Universidad de La Rioja
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Articles

In depth transcriptomic profiling defines a landscape of dysfunctional immune responses in patients with VEXAS syndrome - Nature Communications

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By Shouguo Gao, Zhijie Wu, Massimiliano Bissa, Emma M. Groarke, Haoran Li, Genoveffa Franchini
| Nature Verified
Abstract VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is caused by inactivating somatic mutations in the UBA1 gene. Here, we characterize the immunological landscape of VEXAS syndrome by performing multi-omics single-cell RNA analysis, cytokine multiplex assays, and in vitro functional assays on patients’ peripheral blood. Our data reveals a broad immune system activation with upregulation of multiple inflammatory response pathways and proinflammatory cytokines.
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Patogénesis de los retrovirus en el hombre

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By Genoveffa Franchini
| Dialnet - Universidad de La Rioja
Ayuda Buscar en la ayuda Buscar en la ayuda
Open in Who Shared View Duplicates (350) Issue with article?

Loss of HIV candidate vaccine efficacy in male macaques by mucosal nanoparticle immunization rescued by V2-specific response - Nature Communications

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By Mohammad Arif Rahman, Massimiliano Bissa, Zhong-Min Ma, Anna Gutowska, Christina Luo, Yongjun Sui, Dominic Paquin-Proulx, Mangala Rao, Susan Zolla-Pazner, Timothy J. Cardozo, Genoveffa Franchini
| Nature Verified
Abstract Systemic vaccination of macaques with V1-deleted (ΔV1) envelope immunogens reduce the risk of SIVmac251 acquisition by approximately 60%, with protective roles played by V2-specific ADCC and envelope-specific mucosal IL-17+NKp44+ innate lymphoid cells (ILCs). We investigated whether increased mucosal responses to V2 benefit vaccine efficacy by delivering oral nanoparticles (NPs) that release V2-scaffolded on Typhoid Toxin B (TTB) to the large intestine.
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