Genshu Wang on Muck Rack

Genshu Wang

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Articles

N6-methyladenosine–mediated up-regulation of ARRB2 regulates intrahepatic cholangiocarcinoma malignant progression and pemigatinib resistance through MAPK and Hippo signaling pathways

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By Haoqi Chen, Xiaowen Wang, Wenfeng Zhu, Wenjie Zheng, Qiwei Yang, Zhixing Liang, YUAN ZHANG, Xuejiao Li, Jinliang Liang, Xiaolong Chen, Hua Li, Linsen Ye, Hui Li, Shuguang Zhu, Xijing Yan, Genshu Wang
| Nature Verified
Abstract Intrahepatic cholangiocarcinoma (ICC) is a major contributor to cancer-related mortality on a global scale, yet it suffers from a lack of reliable early diagnostic biomarkers and effective therapeutic targets. Pemigatinib has been identified as a therapeutic option for advanced ICC; however, its long-term clinical efficacy is significantly hindered by the development of drug resistance.
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