Georgios Giamas

Abstract The mortality associated with gastric cancer (GC) is mostly attributed to metastasis that is resistant to therapy, presenting a therapeutic challenge that frequently continues even after effective eradication of Helicobacter pylori (H. pylori). This paper addresses the “eradication paradox” by introducing a novel conceptual framework, the “Survival Switch” hypothesis: H.

Abstract Traumatic brain injury (TBI) is among the most devastating condition and involves primary and secondary injury cascades. The blood-brain barrier (BBB) is a selective, semipermeable membrane that tightly controls the brain’s microenvironment for proper neuronal function. Existing evidence demonstrates that TBI impairs the integrity and function of the BBB, leading to not only acute pathological changes but also long-term neuropathological consequences.

Abstract Temozolomide (TMZ) resistance is one of the critical factors contributing to the poor prognosis of glioblastoma (GBM). As a first-line chemotherapeutic agent for GBM, TMZ exerts its cytotoxic effects through DNA alkylation. However, its therapeutic efficacy is significantly compromised by enhanced DNA damage repair (DDR) mechanisms in GBM cells. Although several DDR-targeting drugs have been developed, their clinical outcomes remain suboptimal.