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Articles by Gérard Eberl
Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells - Nature Immunology
Abstract Prevention and regulation of excessive inflammation is a key target to protect against inflammatory pathologies such as autoimmunity and allergy. In a mouse model of acute lung protease hypersensitivity, we assessed the efficacy of immunological cross-regulation to mitigate pathogenic inflammation.
Towards digitally-enhanced psychiatry
Digital technology is already transforming the world of healthcare, opening up unprecedented prospects. From personalising care to reducing hospital overcrowding, the expectations are astonishing. But for this revolution to live up to its promise, healthcare professionals need to both adopt these tools, while rethinking how they are used.
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut - Nature
Abstract Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell responses, but the mechanisms controlling these distinct outcomes remain poorly understood, and accumulating evidence indicates that aberrant immunity to intestinal microbiota is causally associated with infectious, inflammatory and malignant diseases1,2,3,4,5,6,7,8.
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system - Nature Communications
Mice Adult male C57BL/6J mice (8–10 weeks old) were purchased from Janvier laboratories (St Berthevin, France) and maintained under SPF conditions at the Institut Pasteur animal care facility. Germ-free C57BL/6J mice were generated at the Gnotobiology Platform of the Institut Pasteur and routinely monitored for sterility. Mice were provided with food and water ad libitum and housed under a strict 12-h light–dark cycle.
Beware of whom you live with: Your intestinal IgA may depend on it
Commentary|Basic Gerard Eberl Corresponding Author E-mail address: gerard.eberl@pasteur.fr https://orcid.org/0000-0002-1119-5638 Unité Microenvironnement et immunité, Institut Pasteur, Paris, 75015 France INSERM U1224, Paris, 75015 France Correspondence Gerard Eberl, Unité Microenvironnement et immunité, Institut Pasteur, 75015 Paris, France.
Excess calorie intake early in life increases susceptibility to colitis in adulthood
Abstractand is toxic to colonic epith Epidemiological data reveal an association between obesity and inflammatory bowel disease (IBD). Furthermore, animal models demonstrate that maternal high-fat diet (HFD) and maternal obesity increase susceptibility to IBD in offspring.
GAPs in early life facilitate immune tolerance
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Innate lymphoid cells: A new paradigm in immunology
Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror the phenotypes and functions of T cells. Natural killer (NK) cells can be considered the innate counterparts of cytotoxic CD8 + T cells, whereas ILC1s, ILC2s, and ILC3s may represent the innate counterparts of CD4 + T helper 1 (T H 1), T H 2, and T H 17 cells. However, in contrast to T cells, ILCs do not express antigen receptors or undergo clonal selection and expansion when stimulated.
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