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Articles by Gerardo Rojas-Piloni
Differential participation of the corticospinal and corticorubral neurons during motor execution in the rat
Abstract The sensorimotor cortex is crucial for learning and executing new movements with precision (Nudo & Frost, 2007). It selectively modulates sensory information flow and represents motor information in a spatially organized manner (Canedo, 1997; Chen et al., 2017). The pyramidal system is made up layer 5 pyramidal tract neurons (PTNs), which are organized into populations with distinct morphological, genetic and functional properties.
A shift of brain network hub after spinal cord injury
Introduction Spinal cord injury (SCI) causes dysfunction of the spinal cord at and below the level of injury, followed by impairments such as motor and sensory paralysis. Depending on the extent of the injury, spontaneous recovery is limited and often results in serious sequelae. Worldwide, one million people are affected by SCI each year, yielding a significant social loss (GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators, 2019).
GLP-1 enhances hyperpolarization-activated currents of mouse cerebellar Purkinje cell in vitro
1. Introduction In the mammalian central nervous system, GLP1 is mainly secreted by preglucagonergic neurons in the nucleus tractus solitarius (Larsen et al., 1997) that project widely to many regions of the brain, including the hypothalamus, amygdala, brain stem and cerebellum (Vrang et al., 2007; Llewellyn-Smith et al., 2011).
Mouse corticospinal system comprises different functional neuronal ensembles depending on their hodology
Abstract Background Movement performance depends on the synaptic interactions generated by coherent parallel sensorimotor cortical outputs to different downstream targets. The major outputs of the neocortex to subcortical structures are driven by pyramidal tract neurons (PTNs) located in layer 5B. One of the main targets of PTNs is the spinal cord through the corticospinal (CS) system, which is formed by a complex collection of distinct CS circuits.
Relationships between structure, in vivo function and long-range axonal target of cortical pyramidal tract neurons
First, we determined the respective numbers of PTs that project long-range axons to four of the major subcortical targets of vS11, 8, 16, 17 (Fig. 1a): the posterior medial division of the thalamus (POm), the superior colliculus of the tectum (SC), the pontine nucleus (Pons), and the subnucleus caudalis of the spinal trigeminal tract in the brain stem (Sp5C).
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