Gerone A Gonzales

Abstract Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells (APCs) for cross-priming of CD8+ T cells against cancer. They can capture and cross-present dead cell antigens via DNGR-1 (CLEC9A), a receptor for F-actin exposed on cell corpses. However, cDC1s are scarce in human and murine tumors, and this restricts anticancer immunity.

Editor’s summary Control of endogenous retrovirus (ERV) reactivation is mediated through a T cell–independent (TI) B cell response, but precisely how B cells mediate surveillance and prevention of ERV reactivation is unclear. Yang et al. developed an antigen-baiting assay to detect ERV-reactive B cells in mice, identifying that peritoneal B-1 cells expressing germline-encoded IgM were the major source of anti-ERV antibodies.

Editor’s summary Specific variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased susceptibility to Crohn’s disease (CD), but how LRRK2 contributes to the pathogenesis of CD is not fully understood. Using mice harboring LRRK2 risk alleles, Sun et al. found that hyperactive LRRK2 in macrophages led to impaired autophagy and Paneth cell dysfunction.