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Gerullis Ann-Katrin

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Precursors of exhausted T cells are preemptively formed in acute infection - Nature

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By Ming Wu, Barbara Hoellbacher, Christine Wurmser, Jacqueline Berner, Lara V. Donhauser, Gerullis Ann-Katrin, Ben A Youngblood, Anna M. Schulz, Alfred Zippelius, Percy A. Knolle, Matthias Heinig, Carl-Philipp Hackstein
| Nature Verified
Abstract T cell exhaustion limits effector T cell function in chronic infection and tumors1,2. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions met only upon persisting exposure to antigen and inflammation. In sharp contrast, we found similar T cell populations in the early phase of acute infections1,2.
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