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Gha-Hyun J. Kim on Muck Rack

Gha-Hyun J. Kim

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Articles

The NTR/prodrug revolution: Tools for controlling cell loss and regeneration

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By Gha-Hyun J. Kim, Michael Parsons
| eLife
eLife Assessment This Review Article nicely synthesizes the development, applications, and recent technical advances of the nitroreductase/prodrug system, highlighting how it enables precise spatiotemporal cell ablation and experimental platforms for studying regenerative mechanisms and screening for pro-regenerative or protective compounds.
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The NTR/Prodrug Revolution: Tools for Controlling Cell Loss and Regeneration

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By Michael Parsons, Gha-Hyun J. Kim
| preprints.org
Submitted: 23 February 2026 You are already at the latest version Here, we review the history, advancements, and broad utility of the NTR/prodrug system, and suggest future strategies for developing versatile ablation models. As a chemogenetic tool, the nitroreductase (NTR)/prodrug system enables precise spatiotemporal control over cell ablation.
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