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Gianluca Barba

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Articles

A distinct epigenetic program underlies the 1;7 translocation in myelodysplastic syndromes

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By Valeria Di Battista, Barbara Crescenzi, Valentina Pierini, Gianluca Barba
| Nature Verified
Abstract The unbalanced translocation dic(1;7)(q10;p10) in myelodysplastic syndromes (MDS) is originated by centromeric juxtaposition resulting into 1q trisomy and 7q monosomy. More than half of cases arise after chemo/radio-therapy. To date, given the absence of genes within the centromeric regions, no specific molecular events have been identified in this cytogenetic subgroup.
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