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Gianpietro Semenzato on Muck Rack

Gianpietro Semenzato

As seen in: Nature, The Lancet
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Articles

Transcriptomic landscape of CD8+ and CD4 + T-LGL leukemia revealed the distinct impact of STAT3 and STAT5B activating mutations - Leukemia

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By Vanessa Rebecca Gasparini, Enrico Gaffo, Silvia Orsi, Monica Facco, Flavia Bazzoni, Gianpietro Semenzato, Renato Zambello
| Nature Verified
Abstract The biological basis of the high clinical heterogeneity of T-LGL Leukemia (T-LGLL) is not completely understood and effective therapies for this disease are lacking. Through RNA-Sequencing of purified T-LGLs we reveal gene expression profiles and pathway dysregulations in the major patient subgroups, defined by CD8+ or CD4+ phenotype and STAT3/STAT5B mutational status. Overall, T-LGLL patients exhibited a marked transcriptome dysregulation compared to controls.
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The constitutive activation of STAT3 gene and its mutations are at the crossroad between LGL leukemia and autoimmune disorders - Blood Cancer Journal

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By Gianpietro Semenzato, Antonella Teramo, Vanessa Rebecca Gasparini, Gregorio Barilà
| Nature Verified
Abstract Type T Large Granular Lymphocyte Leukemia (T-LGLL) is a chronic disorder characterized by the abnormal proliferation of clonal cytotoxic T cells.
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Monoclonal B-cell lymphocytosis, monoclonal gammopathy of undetermined significance, and T-cell clones of uncertain significance: are these premalignant conditions sharing a common identity? - PubMed

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By Ghobrial IM, Gianpietro Semenzato, Irene M. Ghobrial, Paolo Ghia
| ncbi.nlm.nih.gov
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