Drs Lopes and Rodriguez debate the real-world trade-offs of frontline regimens, including time toxicity, quality of life, and cost of care. To hear arguments related to the pivotal data supporting frontline EGFR+ mNSCLC therapies — osimertinib- vs amivantamab-based regimens, see Round 1. To hear arguments related to the impact of frontline EGFR+ mNSCLC treatment selection on subsequent available therapies — osimertinib- vs amivantamab-based regimens, see Round 3. Dr Santos Castillero: Round two.