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Preprint Review Version 1 This version is not peer-reviewed Version 1 : Received: 15 December 2023 / Approved: 17 December 2023 / Online: 18 December 2023 (09:36:44 CET) Kauffenstein, G.; Martin, L.; Le Saux, O. The Purinergic Nature of Pseudoxanthoma Elasticum. Preprints 2023, 2023121233. https://doi.org/10.20944/preprints202312.1233.v1 Kauffenstein, G.; Martin, L.; Le Saux, O. The Purinergic Nature of Pseudoxanthoma Elasticum. Preprints 2023, 2023121233.
Abstract Pseudoxanthoma Elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues. Although arterial hypertension (AHT) has been reported in PXE patients, its impact on pathological manifestations has as yet been unexplored. We investigated the consequences of experimental AHT on Abcc6−/− PXE mouse models. Experimental AHT was induced by deoxycorticosterone acetate (DOCA-salt) in uni-nephrectomised mice.
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