Gilyeong Nam

Abstract Iron is vital to living cells, playing a key role in cellular respiration, DNA synthesis, and various metabolic functions. Importantly, cancer cells have a higher dependency on iron compared to normal cells to support their rapid growth and survival. Due to this fact, tumors are more vulnerable to ferroptosis, an iron-dependent form of regulated cell death. Radiation therapy (RT), a standard treatment for many cancer patients, is known to induce ferroptosis.

Abstract : Simple Summary Bile duct cancer (cholangiocarcinoma) is a relatively rare cancer type that has a 5-year survival rate of 26% if diagnosed early, but a survival rate of less than 10% if the cancer has spread to the lymph nodes. Most patients with bile duct cancer are treated with surgery and chemotherapy, which unfortunately is more palliative than curative. In comparison to other gastrointestinal cancers, there are few targeted therapies which are specific to bile duct cancer.