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Bimodal multiphoton catalysis via structural regeneration
Abstract Most of the current photocatalytic methodologies for the generation of reactive radical intermediates have limited redox windows and can operate within a single redox manifold. Here, to overcome these constraints, we report a purely organic photocatalyst that operates via a two-photon excitation mechanism, enabling both oxidative and reductive transformations within a unified platform.
A General Organophotoredox Strategy to Difluoroalkyl Bicycloalkane (CF2‐BCA) Hybrid Bioisosteres**
Research Article Dedicated to Professor Paolo Melchiorre on the occasion of his 50th birthday Graphical Abstract A new class of difluoroalkyl bicycloalkane hybrid bioisostere (CF2-BCA) is reported. These molecules merge the structural and biological benefits of two well-established bioisosteres, profiling their utilization under drug discovery programs.
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