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Giovanni Gambaro on Muck Rack

Giovanni Gambaro

As seen in: Nephrology Dialysis Transplantation
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Articles

Specific heparanase inhibition reverses glucose-induced mesothelial-to-mesenchymal transition

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By Valentina Masola, Simona Granata, Gloria Bellin, Giovanni Gambaro
| Nephrology Dialysis Transplantation Verified
Background. Epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells induced by high glucose (HG) levels is a major biological mechanism leading to myofibroblast accumulation in the omentum of patients on peritoneal dialysis (PD). Heparanase (HPSE), an endoglycosidase that cleaves heparan sulfate chains, is involved in the EMT of several cell lines, and may have a major role in this pro-fibrotic process potentially responsible for the failure of dialysis.
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