Giseli Furlan Corrêa

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description imm13947-sup-0001-Figures.docxWord 2007 document , 1.6 MB Figure S1. Deficiency of IL-1α reduces the weight of adipose tissue in animals fed with HFD and infected with Mycobacterium tuberculosis. (a) WT or IL-1α−/− mice were fed for 12 weeks with a standard diet (Chow) or a high-fat diet (HFD). Animals were infected in Week 9 and evaluated 3 weeks post-infection.

Abstract A low grade and persistent inflammation, which is the hallmark of obesity, requires the participation of NLRP3 and cell death. During Mycobacterium tuberculosis infection, NLRP3 signaling is important for bacterial killing by macrophages in vitro, but was shown to be dispensable for host protection in vivo. We hypothesized that during obesity-tuberculosis comorbidity, NLRP3 signaling might play a detrimental role by inducing excessive inflammation.