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Articles by Giulia Zaffaroni
Convenient Microvolume Nucleic Acid Quantification
Company: ThermoFisher Scientific Product Name: NanoDrop™OneC Microvolume UV-Vis Spectrophotometer Catalog Number: ND-ONE-W The NanoDrop™ One Microvolume UV-Vis Spectrophotometer is an exceptionally easy and convenient instrument for routine sample quantification. One of its greatest advantages is that it requires only 1 µL of sample, making it ideal when sample volume is limited.
Simplifying Western Blot Analysis with Jess
Catalog Number: 004-650 The Jess system from ProteinSimple has completely revolutionized Western blotting by making the entire process faster, easier, and more reproducible. It automates protein separation, detection, imaging, and analysis, greatly reducing hands-on time and variability. The software is especially straightforward, providing clear virtual blots, electropherograms, and quantitative results with minimal effort.
Tailoring Cell Culture Media for Successful Cell Therapy Development
Cell culture media is critical for developing cell therapies, serving as the foundation for growing and maintaining therapeutic cells. This article explores recent innovations in cell culture media, the importance of optimizing media formulations to support cell health and performance, and how to meet the needs of different cell types used in therapies. It also addresses challenges in large-scale manufacturing, cell transport, and regulatory compliance.
Turbocharging Transfers: Enhancing Efficiency With the Trans-Blot Turbo Transfer Pack in Western Blotting
The Good Trans-Blot Turbo transfer packs provide greater transfer efficiency in less time. The Bottom Line This is an easy to use and quick protein transfer apparatus that greatly minimizes the time of Western blotting.
Nourishing Growth and Viability With RPMI-1640 Medium (1X) From Cytiva
We use THP1 membrane proteins for our nanoparticles. This is important because they need to grow in a very specific way and this media allows that.
Easy Plate Reader That Greatly Reduces Length of the Experiment
Product Name: Infinite® M Plex, multimode microplate reader, monochromator optics Catalog Number: 30190085 This is a handy machine for measuring Absorbance, Fluorescence, and Luminescence. I use it specifically to measure the absorbance of my membrane proteins in my BCA assay. This then helps me understand how to dilute it when I need to create my biomimetic lipidic nanoparticles. Extremely easy to set up and utilize and immediate results are given.
Revolutionizing Research: Exploring the Sorvall ST4 Plus Centrifuge Series for High-Performance Lab Centrifugation
Company: Thermo Scientific Product Name: Sorvall ST4 Plus Centrifuge Series Catalog Number: 75009509 This is a great centrifuge that is for spinning things down. It is also part of the greener by-design concept of Thermo Scientific, which is great for creating a green lab like we are trying to do. This centrifuge is utilized by me when I do membrane protein extractions and cell culturing.
A Purifier of RNA That is Simple and Easy to Use
This is extremely useful for me when I am doing PCR. I need a high quantity of RNA and this kit allows me to reach the levels I feel comfortable with to do PCR and understand how my experiments went. This product is extremely easy to use and we use it constantly to characterize the amount of RNA that we can get from this kit and then characterize the RNA through PCR.
A HPLC That Has Precision in Analysis but is Complicated
The Good When it works this machine really gives a lot of useful detail and is extremely important for knowing how our nanoparticles are. The Bad This machine has a lot of defects and needs to constantly be checked and triple checked that it is working because it often can have one of the sensors go wrong. The Bottom Line Sometimes we spend more time making sure that the machine functions correctly than running the actual samples. However, once it works, it works well.
This CellSTACK Culture Chamber is Wonderful at Growing Multiple Cells at Once
The Good Super fast at growing cells. The Bad One needs to buy a lot of them to utilize it over a long period of time and it can be expensive. The Bottom Line This is great for growing a lot of cells at the same time. Just try to use it when you really need it because they can be expensive to buy over a large period of time.
Drug Repurposing Approaches and Successes
What do Viagra, Rogaine, and Latisse have in common? They were all developed to treat hypertension but their side effects led to the drugs being repurposed to treat erectile dysfunction and hair loss as well as stimulate eyelash growth, respectively. Search Drug discovery products Search Now Search our directory to find the discovery-related products for your research needs.
Great Media From Cytiva for J774 Cells
This media is grown for J774 cells which are extremely specific in the type of way they like to grow. This media has the right combination that makes them grow well. Although there are other name brands for media this one works just like the rest of them.
Good Anti-Human HLA-DR-BV421 Antibody From BioLegend Ideal for Flow
This type of dish is perfect for J774 cells that are grown in my lab. They are floating cells and these dishes allow them to grow and expand even though they ... read more
Fast and Wonderful ChemiDoc Imaging System From Bio-Rad for Western Blotting
The Good Super fast and accurate, and has both an automatic button or a manual button in case the machine is having difficulty reading. The Bottom Line This is a great product for doing electrophoresis or Western Blotting. I use it for protein Western Blotting and it works wonderfully and it is super easy to use. Highly recommend.
Normal Tissue Culture Flask From Fisher Scientific
The Good Easy to use and large. The Bad Can be expensive if you buy the big packs. The Bottom Line Highly recommended. Cells grow well and don't have mycoplasma infections thus far so filter is working well.
A Satisfactory DNA Quantification Kit for Low-Accuracy Applications
The Good Quick to use, and cheap. The Bad Not accurate enough for high sensitivity applications such as next-gen sequencing. The Bottom Line A more accurate DNA quantification kit than running samples on a Nano drop, but less accurate than running on a bioanalyzer/tapestation.
Great Microscope From Fisher Scientific for Beginners
The Good It is easy to use. The Bad The accuracy of the image doesn't match up to viewing the microscope from the actual lense. The Bottom Line This microscope is super easy to use especially for first time users in the cell culture lab. It enlarges the image so that you can see clearly what is in your flask. Unfortunately, the quality of the image is diminished so more experienced users may like to use a normal microscope. Share your experience with other scientists. Write a Review! »
Artificial Intelligence in Therapeutic Antibody Discovery
Drug development can be a very lucrative, and very costly, venture. Many more drugs fail in early stages—and even worse, in late stages—than succeed, driving up the average time to bring a new drug to market to about 12 years, at a cost of about $1.3 billion. Like many other segments, developers of antibody-based pharmaceuticals are exploring new ways to accelerate development and reduce late-stage failures.
Good Bead Bath From Lab Armor for the Heating of Media
The Good It successfully heats up materials. The Bad It takes around 30+ minutes to do it and sometimes the beads do get cold and you have to move the media etc. The Bottom Line This is a pretty reliable product that successfully heats things up but sometimes if you put too many things into the bead bath it takes more than 30 minutes to heat up.
Great Staining Solution From Thermo Fisher for Seeing Membrane Proteins on Western Blot
Company: Thermo Fisher Scientific Product Name: Ponceau S Staining Solution Catalog Number: A40000279 Thermo Scientific's Ponceau S Staining Solutionis a convenient solution for assessing the transfer efficiency of western blots on nitrocellulose and PVDF membranes. An added advantage is that Ponceau S staining is reversible and can be easily removed with a brief incubation in 0.1% NaOH, allowing for subsequent analysis or reprobing of the same membrane.
Opti-MEM (1X) Works as a Good Media for Cells
The Good It works perfectly and the cells seem to really like it. The Bad There is little availability of this product so make sure to order ahead of time. The Bottom Line Opti-MEM™ I Reduced-Serum Medium offers several valuable advantages. Firstly, it allows researchers to significantly cut down the use of Fetal Bovine Serum in cell culture, helping to reduce costs and address ethical concerns related to its production.
Very Good Brilliant Violet 650™ Anti-Human CD14 Antibody From BioLegend
The Good Able to titrate and still retain clear, distinct staining. The Bad Used in a large panel so extra care had to be taken to avoid overlap with other fluorophores. The Bottom Line Antibody resulted in very clear, distinct staining of monocytes within a large multi-colour panel.
Study on the EGF - ERK Activity With Animal-Free Recombinant Human EGF From Pacific Coast Biologics
The Good Pacific Coast Biologics Human EGF worked great as an ERK pathway activator. The Bottom Line Our research is centered around the design and application of synthetic ligands to better understand receptor-level mechanisms of signal activation and demonstrate their potential for tissue engineering. We use natural ligands as a benchmark for standard pathway activity and to determine the potency of our synthetic ligands.
Great DNA Stain for qPCR From Invitrogen
The Good Sensitive and cheap. The Bad Does require some optimization for specific applications. The Bottom Line A great general purpose DNA stain for qPCR after the protocol has been properly optimized for the specific application/amplification being performed.
This Adipogenesis Differentiation Kit From Gibco is a Good Tool to Help Cells Differentiate Into Adipocyte
The Good The product's key advantage lies in its ability to support efficient and consistent adipocyte differentiation, offering a valuable tool for researchers in the field. The Bad The drawback of this product is its relatively high cost, which may pose a budget constraint for some research projects.
10x Tris/Glycine/SDS From Bio-Rad Produces Good SDS Pages
The Good SDS-PAGE is appreciated for its user-friendly setup and straightforward protocol, making it accessible to a wide range of researchers in the life sciences. The Bad Unfortunately, results are confusing, and an SDS-PAGE can be misused to manipulate or misrepresent experimental results, undermining the credibility of research findings.
High Quality Rheometer From Anton Paar for Measuring Pluronics
The Good The rheometer provide invaluable insights into the complex flow and deformation behaviors of materials, advancing research and innovation in various industries. The Bad While the rheometer is an indispensable tool for understanding material properties, their complexity and cost can sometimes present barriers to widespread accessibility and utilization.
Satisfactory PCR Tubes From Applied Biosystems™
The Good MicroAmp Fast Reaction Tubes excel in PCR applications, reliably enduring thermal cycling and chemical exposure while consistently delivering accurate results. The Bad Some users have reported occasional issues with the sealing caps of MicroAmp Fast Reaction Tubes, leading to possible sample contamination in rare cases. The Bottom Line MicroAmp Fast Reaction Tubes are a dependable choice for PCR applications due to their durability, resistance to thermal cycling, and precision.
Good Protein Extraction Kit From Sigma Aldrich Requiring Protocol Modifications
The Good This gives a good product that gives you membrane proteins. The Bad The quantity of the proteins varies a lot by how many cells you start the dilution from. The Bottom Line This is a good product, but you might have to make your own protocol to maximize the amount of proteins.
Accurate Results Can be Obtained Using the Pierce™ Rapid Gold BCA Protein Assay Kit
The Good Reliable and fast signal. The Bad You must make sure that you pipette well or else your results will not come out well. The Bottom Line This is a fast and reliable product to understand how to quantity protein concentrations.
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