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Giuseppe Stefano Morino on Muck Rack

Giuseppe Stefano Morino

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Articles

Biomarkers of Alzheimer Disease, Insulin Resistance, and Obesity in Childhood

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By Rosa Luciano, Gloria Maria Barraco, Maurizio Muraca, Simonetta Ottino, Maria Rita Spreghini, Rita Wietrzykowska Sforza, Carmela Rustico, Giuseppe Stefano Morino
| Pediatrics Verified
OBJECTIVE: To answer the question of whether onset of insulin resistance (IR) early in life enhances the risk of developing dementia and Alzheimer disease (AD), serum levels of 2 molecules that are likely associated with development of AD, the amyloid β-protein 42 (Aβ42) and presenilin 1 (PSEN1), were estimated in 101 preschoolers and 309 adolescents of various BMI. METHODS: Participants (215 boys; 48.8%) were normal weight (n = 176; 40%), overweight (n = 135; 30.7%), and obese (n = 129; 29.3%).
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