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Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia

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By Glantz LA, Lewis DA
| JAMA Psychiatry Verified
Background  The pathophysiological characteristics of schizophrenia appear to involve altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that layer 3 pyramidal neurons play in corticocortical and thalamocortical connectivity, we hypothesized that the excitatory inputs to these neurons are altered in subjects with schizophrenia.
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