Gokhan METAN

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1. Introduction Antibiotic resistance is a significant and growing global problem that poses a serious threat to public health, especially with respect to healthcare-acquired (HA) infections [1]. Vancomycin-resistant Enterococcus faecium (VRE) is one of the leading causes of HA infections [2]. Bloodstream infections (BSIs) that are caused by VRE are associated with significant morbidity and mortality. Mortality rates range between 20% and 52% [3,4,5,6,7].

HIGHLIGHTS • The growing problem of antibiotic resistance is a major public health concern. • An antimicrobial stewardship study was conducted in intensive care units. • There was a significant increase in total quality-of-care scores. ABSTRACT Background One of the most important public health concerns is the ever-growing problem of antibiotic resistance. Importantly, the rate of introduction of new molecules into clinical practice has slowed down considerably.