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Gokulakrishna Banumurthy on Muck Rack

Gokulakrishna Banumurthy

As seen in: Nature
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Articles

Glutamate concentration tunes AMPA receptor function through conductance-state occupancy

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By Reagan L. Pennock, Luke T. Coddington, Xiaohui Yan, Gabrielle Smith, Linda Overstreet-Wadiche, Jacques I. Wadiche, Gokulakrishna Banumurthy
| Nature Verified
Abstract α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) mediate excitatory synaptic transmission across the brain and exhibit distinct modes of opening depending on how much glutamate is bound. Despite extensive work on AMPAR conductance states and subunit composition, whether changes in glutamate levels at and around synapses regulate AMPAR function is unknown.
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