Graham Taylor
Arizona
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Articles by Graham Taylor
A continental-scale dataset of ground beetles with high-resolution images and validated morphological trait measurements
Abstract Despite the ecological significance of invertebrates, global trait databases remain heavily biased toward vertebrates and plants, limiting comprehensive ecological analyses of high-diversity groups like ground beetles. Ground beetles (Coleoptera: Carabidae) serve as critical bioindicators of ecosystem health, providing valuable insights into biodiversity shifts driven by environmental changes.
Tennessee should not turn its back on mRNA innovation | Opinion
Medical breakthroughs do not happen overnight. They are the result of decades of research, investment and the freedom to pursue scientific innovation.
Tennessee should not turn its back on mRNA innovation | Opinion
Medical breakthroughs do not happen overnight. They are the result of decades of research, investment and the freedom to pursue scientific innovation.
Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma
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Abstract Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (EBV⁺DLBCL) is an aggressive lymphoma with poor outcomes and an incompletely understood pathogenesis, frequently attributed to immunosenescence. However, its occurrence across all age groups suggests alternative mechanisms.
By Eanna Fennell, Soi C. Law, Alexander C. Dowell, Matthew Pugh, Christina Enright, Aisling M Ross, Ciara Leahy, Nadezhda Nikulina, Alex Richter, Lucia Mundo, Lorenzo Leoncini, Stefano Lazzi, Maria Chiara Siciliano, Stefan Dojcinov, Leticia Quintanilla-Martínez, Ken Young, Maher Gandhi, Graham Taylor, Paul Murray, Aoife S. Hennessy
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Nature
Verified
A multi-modal dataset for insect biodiversity with imagery and DNA at the trap and individual level
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Abstract Insects comprise millions of species, many experiencing severe population declines under environmental and habitat changes. High-throughput approaches are crucial for accelerating our understanding of insect diversity, with DNA barcoding and high-resolution imaging showing strong potential for automatic taxonomic classification. However, most image-based approaches rely on individual specimen data, unlike the unsorted bulk samples collected in large-scale ecological surveys.
By Nicolas Chazot, Jeremy deWaard, Brendan Furneaux, Bess Hardwick, Nao Ito, Amlan Kar, Deirdre Kerdraon, Erik Kristensen, Tomas Roslin, Paula Schmitz, Jayme Sones, Maija Sujala, Amy Thompson, Evgeny V. Zakharov, Akshita Gupta, Scott Lowe, Graham Taylor, Johanna Orsholm, John Quinto, Hannu Autto, Gaia Banelyte, Stephanie deWaard, Arielle Farrell, Oula Kalttopää, Jaclyn McKeown, Tommi Mononen, Ellen Nein, Iuliia Zarubiieva
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Nature
Verified
Fifth Season Launches Non-Scripted Banner Quite Contrary Pictures With Mary Lisio
Fifth Season is launching a new non-scripted production banner, Quite Contrary Pictures, which will be run by its EVP of non-scripted development and production, Mary Lisio. Lisio, who won an Emmy as a producer of the History Channel’s “Gettysburg,” will serve as president of Quite Contrary, building out a slate of documentary features, docuseries and reality formats.
Lupus may be triggered by a common virus – new research
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Lupus may be triggered by a common virus - new research
Epstein-Barr virus is a type of herpesvirus. Kateryna Kon/ Shutterstock Around 5 million people worldwide live with the autoimmune condition lupus. This condition can cause a range of symptoms, including tiredness, fever, joint pain and a characteristic butterfly-shaped rash across the cheeks and nose. For some people, these symptoms are mild and only flare-up occassionally.
HIV in pregnancy
Dr Anna Powell would like to gratefully acknowledge Dr Rachel K. Scott, Dr Isaac Delke, Dr Christina Bailey, and Dr Mettassebia Kano, the previous contributors to this topic. Disclosures RKS declares that she has participated in an advisory meeting for ViiV Healthcare and has received research funding from ViiV, managed by MedStar Health Institute. ID, CB, and MK declare that they have no competing interests.
Coega SEZ built at huge cost has failed to live up to its promise
FUNDING SUPPORT: The Coega Development Corporation (CDC) special economic zone (SEZ) Dr Luvuyo Bono’s opinion (The Herald — Friday August 8) on the state of industry in our city is a welcome recognition of the need for collaborative leadership to rebuild our devastated economy. So is the Peter Bruce point in the accompanying opinion — that we are broken by years of misrule.
Detect+Track: Robust and flexible software tools for improved tracking and behavioural analysis of fish
Abstract Developments in automated animal behavioural analysis software are increasing the efficiency of data collection and improving the standardization of behavioural measurements. There are now several open-source tools for tracking laboratory animals, but often these are only accurate under limited conditions (e.g. uniform lighting and background, uncluttered scenes, unobstructed focal animal).
Democracy is not something you give up on
It feels like Groundhog Day — that movie where you wake up to the same situation as yesterday. A new government, but the same old issues. Decaying infrastructure, crime, collapsing governance, and tomorrow it’s the same old story again. It’s hard not to feel despondent — especially in civil society — where no good deed goes unpunished. The news that Friends of the Baviaanskloof Wilderness Area (FOBWA) is closing down is bad for democracy (The Herald, July 23).
High HTLV-1 Proviral Load Predates and Predicts HTLV-1-Associated Disease: Literature Review and the London Experience
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Epstein-Barr virus: How does a common infection trick the immune system into attacking the brain in people with MS?
Almost 3 million people worldwide have multiple sclerosis (MS)—an autoimmune disease caused by the immune system mistakenly attacking the brain and central nervous system. While treatments for MS have improved over the years, there's still no cure. This is largely because researchers still don't fully understand what goes wrong in the immune system to cause MS. But our latest research has revealed new insights into the way certain immune cells behave in people with MS.
Epstein-Barr virus: how does a common infection trick the immune system into attacking the brain in people with MS?
Epstein-Barr virus: how does a common infection trick the immune system into attacking the brain in people with MS? Almost 3 million people worldwide have multiple sclerosis (MS) – an autoimmune disease caused by the immune system mistakenly attacking the brain and central nervous system. While treatments for MS have improved over the years, there’s still no cure. This is largely because researchers still don’t fully understand what goes wrong in the immune system to cause MS.
Rewriting the past leaves us with names stripped of meaning
Historical Society of Port Elizabeth chair Graham Taylor The Herald opinion piece on geographic renaming (Rewriting the narrative of our past, present and future, The Herald May 21) confirms the decolonisation bias of the department of sport, recreation, arts and culture. The department argues that geographic renaming is an act of reparation and visual redress through the change of colonial place names to indigenous names. If only things were that simple.
Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children - Nature Communications
Abstract Multisystem inflammatory syndrome in children is a post-infectious presentation SARS-CoV-2 associated with expansion of the T cell receptor Vβ21.3+ T-cell subgroup. Here we apply muti-single cell omics to compare the inflammatory process in children with acute respiratory COVID-19 and those presenting with non SARS-CoV-2 infections in children.
How Central can become a place of art
How Central can become a place of art By Graham Taylor - 21 January 2024 Clayton Holliday (1930-2023) passed away peacefully on November 25 2023 at the age of 93. His was a life devoted to the arts, becoming the face of the vibrant Central area of Port Elizabeth between 1972 and 1987...
Public library provides ray of hope amid rundown city centre
REVIVING ECONOMY: Tourists ready to explore what’s on offer. A combined 4,764 passengers arrived in the Bay aboard three cruise liners The Weekend Post (This is what city wants tourists to see — December 9) views a municipal safety pamphlet as a map that leads unwitting tourists to known crime hotspots and squalor. In fairness to city officials, safety tips cannot escape one inconvenient truth. Tourists flock to products they want. Those wants are simple; a unique, safe and stimulating experience.
Looking back: crime can be fixed with citizen action
The top 30 police stations with the highest contact crime cases are in four provinces. File image So it’s confirmed, Nelson Mandela Bay is the most dangerous metro in SA (The Herald Editorial November 16). We bemoan the decline of the economy, blame politicians and point to the rampant corruption under the ANC. At face value, the solutions are simple. Policemen must be appointed, and law and order must prevail — we nod in agreement.
Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes - Nature Communications
Abstract We report on single-molecule nanopore sensing combined with position-encoded DNA molecular probes, with chemistry tuned to simultaneously identify various antigen proteins and multiple RNA gene fragments of SARS-CoV-2 with high sensitivity and selectivity. We show that this sensing strategy can directly detect spike (S) and nucleocapsid (N) proteins in unprocessed human saliva.
Patient research priority setting partnership in human T‐cell lymphotropic virus type I
1 BACKGROUND There is no cure or vaccine for human T-cell lymphotropic virus type 1 (HTLV-1). In England and Wales, approximately 22,000 people live with HTLV-1,1 the majority are women (65%), of Black Caribbean ethnicity (60%) and born outside the United Kingdom (72%).2 This underserved community of people living with a rare condition were empowered to identify their research priorities.
The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle
Discrete changes to cell state occur following HTLV-1 reactivation To obtain an overview of the changes in gene expression underlying differences between measurements at different timepoints, we performed differential expression analysis of Kallisto transcript pseudocounts using DESeq2 [38].
Projections of Large-Scale Atmospheric Circulation Patterns and Associated Temperature and Precipitation Over the Pacific Northwest Using CMIP6 Models
Abstract Climate model projections of atmospheric circulation patterns, their frequency, and associated temperature and precipitation anomalies under a high-end global warming scenario are assessed over the Pacific Northwest of North America for the final three decades of the 21st century.
Imaging Spectrum of HTLV-1-Related Neurologic Disease
There is currently no cure for HTLV-1–related neurologic diseases. Interferon α has shown some therapeutic benefit in a randomized control trial (RCT) in patients with HAM, but the efficacy is limited, and the treatment is rarely used due to potential risks.56,57 Corticosteroids are presently the mainstay of therapy and are used to suppress inflammation and improve or maintain long-term neurologic function.
Getting the bugs out of AI: Advancing ecological research on arthropods through computer vision
DISCUSSION The urgency of insect collapse falls back to one main motivation: what is the shortest path to improving the speed and accuracy of ecological monitoring of insects on a global scale? We believe the answer to this question is the pursuit of a single, publicly available, general purpose foundation model of entomology.
Watford appoint their 18th different permanent manager since 2010
Watford appoint their 18th different permanent manager since 2010, bringing in Valérien Ismaël as replacement for Chris Wilder. Chris Wilder’s contract expired after the win against Stoke City on Monday, and the Hornets have wasted no time in bringing in the 47-year old ex-Barnsley, West Brom and Besiktas manager takes over. Ismael came to the UK’s attention when he became the manager of Barnsley in Autumn 2020.
A robust and flexible deep-learning workflow for animal tracking
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Ultra-fast micro-CT of an unrestrained live insect
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Zebra finches use brightness cues for gap selection in flight
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The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle
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Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19 - Nature Communications
Abstract Although alterations in myeloid cells have been observed in COVID-19, the specific underlying mechanisms are not completely understood. Here, we examine the function of classical CD14+ monocytes in patients with mild and moderate COVID-19 during the acute phase of infection and in healthy individuals. Monocytes from COVID-19 patients display altered expression of cell surface receptors and a dysfunctional metabolic profile that distinguish them from healthy monocytes.
Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition - Nature Immunology
Abstract CD4+ T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of CD4+ T cells to mutations in SARS-CoV-2 variants of concern (VOCs) is poorly understood. Here, we isolated 159 SARS-CoV-2-specific CD4+ T cell clones from healthcare workers previously infected with wild-type SARS-CoV-2 (D614G) and defined 21 epitopes in spike, membrane and nucleoprotein.
Embrace wobble to level flight without a horizon
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Why hawks are one of nature’s deadliest hunters
By Graham Taylor for 'The Conversation' The sight of hundreds of thousands of bats streaming from their roost at dusk is one of nature’s great spectacles. Swarms can be so dense they resemble rising smoke at a distance. But the aerial antics of the birds of prey that hunt them are just as astonishing.
Role of AI and digital pathology for colorectal immuno-oncology - British Journal of Cancer
Abstract Immunotherapy deals with therapeutic interventions to arrest the progression of tumours using the immune system. These include checkpoint inhibitors, T-cell manipulation, cytokines, oncolytic viruses and tumour vaccines. In this paper, we present a survey of the latest developments on immunotherapy in colorectal cancer (CRC) and the role of artificial intelligence (AI) in this context. Among these, microsatellite instability (MSI) is perhaps the most popular IO biomarker globally.
Graham Taylor on Fstoppers
September 21, 2020 Natural light with personal car, 1974 Camaro Z28. In Lists 6014 7
Dynamics of a national Omicron SARS-CoV-2 epidemic during January 2022 in England - Nature Communications
Abstract Rapid transmission of the SARS-CoV-2 Omicron variant has led to record-breaking case incidence rates around the world. Since May 2020, the REal-time Assessment of Community Transmission-1 (REACT-1) study tracked the spread of SARS-CoV-2 infection in England through RT-PCR of self-administered throat and nose swabs from randomly-selected participants aged 5 years and over.
Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England - Nature Communications
Abstract The SARS-CoV-2 pandemic has been characterised by the regular emergence of genomic variants. With natural and vaccine-induced population immunity at high levels, evolutionary pressure favours variants better able to evade SARS-CoV-2 neutralising antibodies. The Omicron variant (first detected in November 2021) exhibited a high degree of immune evasion, leading to increased infection rates worldwide.
Graham Taylor on Fstoppers
MKXVI Spitfire TE311 of the Battle of Britain Memorial Flight, Royal Air Force, igniting unburnt fuel on start-up. 140mm · f/3.2 · 1/1600s · ISO 400
Optimization of avian perching manoeuvres - Nature
Abstract Perching at speed is among the most demanding flight behaviours that birds perform1,2 and is beyond the capability of most autonomous vehicles. Smaller birds may touch down by hovering3,4,5,6,7,8, but larger birds typically swoop up to perch1,2—presumably because the adverse scaling of their power margin prohibits hovering9 and because swooping upwards transfers kinetic to potential energy before collision1,2,10.
Frosted Blue Hues With Hills & Harbour Gin by Crafty Distillery
There's a fine line between bold and elegant, but Hills & Harbour Gin's packaging balances the act designed by Graham Taylor and Sarah Graham. The frosted blue glass creates a sleek shell, while the green and blue typography help elevate the bottle further. And in addition to the beautiful color palette, the natural wood top and cork stopper double as a measuring glass. This bottle design is naturally enchanting.
HTLV-1 encephalitis
HTLV-1 encephalitis Josh King-Robson1, Timothy Hampton2, Carolina Rosadas3, Graham P Taylor3, Biba Stanton1 1 Neurology Department, King's College Hospital, London, UK 2 Neuroradiology Department, King's College Hospital, London, UK 3 Department of Infectious Disease, Imperial College London, London, UK Correspondence to Dr Josh King-Robson, Neurology Department, King's College Hospital, London SE5 9RS, UK; j.king-robson{at}nhs.net Abstract A 53-year-old woman developed subacute onset of...
HTLV-1 encephalitis
HTLV-1 encephalitis Josh King-Robson1, Timothy Hampton2, Carolina Rosadas3, Graham P Taylor3, Biba Stanton1 1 Neurology Department, King's College Hospital, London, UK 2 Neuroradiology Department, King's College Hospital, London, UK 3 Department of Infectious Disease, Imperial College London, London, UK Correspondence to Dr Josh King-Robson, Neurology Department, King's College Hospital, London SE5 9RS, UK; j.king-robson{at}nhs.net Abstract A 53-year-old woman developed subacute onset of...
Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts - Nature Communications
Abstract Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 exposure.
Health inequities and HTLV-1
WHO defines health inequities as “systematic differences in the health status of different population groups. These inequities have significant social and economic costs both to individuals and societies”. By definition, health inequities are unfair and potentially avoidable with the implementation of adequate policies.
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection - Nature Immunology
Sample collection Public Health England (PHE) initiated prospective SARS-CoV-2 surveillance in primary schools across the UK after they reopened following the easing of national lockdown in June 2020. The protocol for sKIDs is available online (https://www.gov.uk/guidance/covid-19-paediatric-surveillance)16.
Trade facilitation at the Coega Special Economic Zone
Trade facilitation is a newly established focus area at the Coega Special Economic Zone (SEZ), located in the City of Gqeberha, Nelson Mandela Bay Municipality, South Africa. The focus area brings together customs, investor services, and logistics to the internationally acclaimed and award-winning 9003ha Coega SEZ and Nelson Mandela Bay Logistics Park (NMBLP), says Graham Taylor, CDC’s trade facilitation manager.
Trade facilitation at the Coega Special Economic Zone
Trade facilitation is a newly established focus area at the Coega Special Economic Zone (SEZ), located in the City of Gqeberha, Nelson Mandela Bay Municipality, South Africa. The focus area brings together customs, investor services, and logistics to the internationally acclaimed and award-winning 9003ha Coega SEZ and Nelson Mandela Bay Logistics Park (NMBLP), says Graham Taylor, CDC’s trade facilitation manager.
HTLV-1 encephalitis
HTLV-1 encephalitis Josh King-Robson1, Timothy Hampton2, Carolina Rosadas3, Graham P Taylor3, Biba Stanton1 1Neurology Department, King's College Hospital, London, UK 2Neuroradiology Department, King's College Hospital, London, UK 3Department of Infectious Disease, Imperial College London, London, UK Correspondence to Dr Josh King-Robson, Neurology Department, King's College Hospital, London SE5 9RS, UK; j.king-robson{at}nhs.net Abstract A 53-year-old woman developed subacute onset of upper...
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