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Max Crispin on Muck Rack

Max Crispin

Southampton
As seen in: Nature, BioRxiv, Cell Press, Cell Reports, The Journal of Biological Chemistry
Director, Institute for Life Sciences & Professor of Glycobiology at the University of Southampton. Personal tweets.
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Articles

Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading

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By Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel Bader, Ryan Lim, Krystal M. Ma, Christopher A. Cottrell, Jon M. Steichen, Liling Xu, Paula M. Villavicencio, Madhav Akauliya, Ja-Hyun Koo, Jacqueline Shen, Alexandra Vernich, Oleksandr Kalyuzhniy, Joel Allen, Ali Albowaidey, Anthony Alicea, Bingxian Chen, Erik Georgeson, Nushin Alavi, Abigail Esposito, Nicole Phelps Verified, Michael Kubitz, Quynh Anh Phan, Alessia Liguori, Thavaleak Prum, Ryan Tingle, Danny Lu, Saman Eskandarzadeh, John Warner, Stephanie R. Weldon, Sunny Himansu, Max Crispin, Usha B. Nair, Sophia Liu, William R. Schief, Facundo D. Batista, Jordan Renae Ellis-Pugh, Hannah Naili, Brendon Kelley, Xiaotie Liu
| Cell Press Verified
Keywords B cell germinal center antibody feedback affinity maturation HIV vaccine sequential immunization plasma cells local antibody pool Introduction Affinity maturation is the fundamental process underpinning the humoral response to infection or vaccination.1,2 Exposure to antigen activates a polyclonal B cell response derived from those cells with B cell receptors (BCRs) meeting a minimum affinity threshold.3 Those with very high initial affinities will differentiate into extrafollicular...
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Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design - Nature Communications

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By Linling He, Yi-Zong Lee, Yi-Nan Zhang, Maddy L. Newby, Benjamin M. Janus, Garrett V Ward, Erick Giang, Joel Allen, Liudmila Kulakova, Eric A. Toth, Thomas R. Fuerst, Mansun Law, Gilad Ofek, Max Crispin, Jiang Zhu, Fabrizio G. Gonzalez, Connor DesRoberts, Shr-Hau Hung
| Nature Verified
Abstract Hepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. Development of an E1E2-based HCV vaccine has been hindered by the difficulty of producing a soluble E1E2 (sE1E2) antigen that faithfully recapitulates the native virion-associated heterodimer.
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Molecular parameters governing antibody FcγR signaling and effector functions in the context of HIV envelope

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By Michael Bick, Eduard Puig, David Beauparlant, Rebecca Nedellec, Raiza Bastidas, Javier Guenaga, Wen-Hsin Lee, Richard Wyatt, Wenwen Zhu, Max Crispin, Gabriel Ozorowski, Andrew Ward, Dennis R. Burton, Lars Hangartner, Iszac Burton, Keihvan Ardaghi, Thea R. Zalunardo, Xuduo Li
| Cell Reports Verified
Expression constructs In silico structure prediction and probabilistic network interaction analysis Amino acids 31–663 of RT design candidates were subjected to structure prediction as a trimer using the AlphaFold2 multimer algorithm. Resulting predictions were structurally aligned and combined into a single multi-state file in PyMol 2.5.0 before they were subjected to probabilistic network analysis using the RING3.0 software package.
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