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Golnaz Ranjbari on Muck Rack

Golnaz Ranjbari

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A high affinity switch for cAMP in the HCN pacemaker channels - Nature Communications

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By Alessandro Porro, Jana Kusch, Klaus Benndorf, Roberta Castelli, Bianca Introini, Golnaz Ranjbari, Dario DiFrancesco
| Nature Verified
Abstract Binding of cAMP to Hyperpolarization activated cyclic nucleotide gated (HCN) channels facilitates pore opening. It is unclear why the isolated cyclic nucleotide binding domain (CNBD) displays in vitro lower affinity for cAMP than the full-length channel in patch experiments. Here we show that HCN are endowed with an affinity switch for cAMP. Alpha helices D and E, downstream of the cyclic nucleotide binding domain (CNBD), bind to and stabilize the holo CNBD in a high affinity state.
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