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Articles by Goo Jun
Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality
IMPORTANCE: Alcohol drinking and obesity are associated with an increased risk of cirrhosis and hepatocellular carcinoma (HCC), but the risk is not uniform among people with these risk factors. Genetic variants, such as I148M in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene, may play an important role in modulating cirrhosis and HCC risk.
X‐linked genetic associations in sporadic thoracic aortic dissection
CONFLICT OF INTEREST STATEMENT DK is a scientific advisor and reports consulting fees from Bitterroot Bio, Inc unrelated to the present work. The rest of the authors have no conflicts of interest to disclose. Supporting Information Filename Description ajmga63644-sup-0001-FigureS1.pdfPDF document, 47 KB Figure S1. Q–Q plot for the observed X chromosome-wide distribution of the test statistic from the expected null distribution in the discovery cohort.
"The impact of the Th17:Treg axis on the IgA-Biome across the glycemic " by Heather T Essigmann, Kristi L Hoffman et al.
Abstract Secretory IgA (SIgA) is released into mucosal surfaces where its function extends beyond that of host defense to include the shaping of resident microbial communities by mediating exclusion/inclusion of respective microbes and regulating bacterial gene expression. In this capacity, SIgA acts as the fulcrum on which host immunity and the health of the microbiota are balanced.
Causal association between serum total bilirubin and cholelithiasis: a bidirectional two-sample Mendelian randomization study
1 Background The high number of individuals affected by cholelithiasis (gallstone disease), estimated to be 10%–20% of the adult population, has posed a major financial strain on society around the world (1). An enormous amount of work has gone into determining the risk factors that lead to the development of cholelithiasis to alleviate this health burden. Most gallstones are found in the gallbladder (cholecystolithiasis).
StocSum: stochastic summary statistics for whole genome sequencing studies
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Structural variation across 138,134 samples in the TOPMed consortium
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Identifying Individualized Risk Profiles for Radiotherapy-Induced Lymphopenia Among Patients With Esophageal Cancer Using Machine Learning
Abstract Radiotherapy (RT)-induced lymphopenia (RIL) is commonly associated with adverse clinical outcomes in patients with cancer. Using machine learning techniques, a retrospective study was conducted for patients with esophageal cancer treated with proton and photon therapies to characterize the principal pretreatment clinical and radiation dosimetric risk factors of grade 4 RIL (G4RIL) as well as to establish G4RIL risk profiles.
Whole Exome Sequencing to Identify Genetic Variants Associated with Raised Atherosclerotic Lesions in Young Persons
Previous studies have identified genes containing variants that are associated with clinical CAD, yet the major portion of CAD genetic heritability remains to be explained2. In this study, we are using PDAY for genetic studies to reduce the phenotypic heterogeneity inherent in clinical CAD, and to provide quantitative measures of subclinical CAD (raised atherosclerotic lesions) that accumulate over time and can eventually result in clinical CAD.
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