Grace Anderson-Barker

1 INTRODUCTION Isolated perfused small animal hearts have been used extensively for cardiotoxicity and pharmacological testing (Bell et al., 2011; Liao et al., 2012; Louradour et al., 2023; Pouna et al., 1996; Sutherland et al., 2003; Suzer et al., 1998). While many mammalian species have been studied, hearts isolated from rats and mice appear in >70% of the isolated heart literature.

Abstract Introduction: A variety of QT rate-correction (QTc) formulae have been utilized for both clinical and research purposes. However, these formulae are not universally effective, likely due to significant influences of demographic diversity on the QT–HR relationship. To address this limitation, we proposed an adaptive QTc (QTcAd) formula that adjusts to subject demographics (i.e., age). Further, we compared the efficacy and accuracy of the QTcAd formula to other widely used alternatives.