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Grace E. McAuley on Muck Rack

Grace E. McAuley

As seen in: BioRxiv, Cell Press
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Articles by Grace E. McAuley

Successful Gene Editing of Apolipoprotein E4 to E3 in Brain of Alzheimer Model Mice After a Single IV Dose of Synthetic Exosome-Delivered CRISPR

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By Jesus Campagna, Chunni Zhu, Grace E. McAuley, Bruce Teter
| BioRxiv
Abstract Background. The gene for apolipoprotein E4 (ApoE4 E4) confers an increased risk for development and lowers the age of onset of Alzheimers disease (AD). It is a highly suitable target for CRISPR-based editing because ApoE4 differs from ApoE3 by a single nucleotide polymorphism in the codon for residue 112 that codes for arginine (CGC) in E4 and cysteine (TGC) in E3. Editing of E4 to E3 could lower the risk of AD or ameliorate E4-related AD phenotypes.
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Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing

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By Grace E. McAuley, Gloria Yiu, Patrick Chang, Gregory A. Newby
| Cell Press Verified
Garcillán B. Fuentes P. Marin A.V.v. Megino R.F. Chacon-Arguedas D. Mazariegos M.S. Jiménez-Reinoso A. Muñoz-Ruiz M. Laborda R.G. Cárdenas P.P. et al. CD3G or CD3D knockdown in mature, but not immature, T lymphocytes similarly cripples the human TCRαβ complex. Front. Cell Dev. Biol. 2021; 9: 608490https://doi.org/10.3389/fcell.2021.608490 Dadi H.K. Simon A.J. Roifman C.M. Effect of CD3 d deficiency on maturation of a/b and g/d T-cell lineages in severe combined immunodeficiency. N. Engl. J. Med.
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