Grace Egan
As seen in:
Medium,
Nature,
Cell Press,
Dialnet - Universidad de La Rioja,
Cancer Discovery,
Daily Lobo
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Articles by Grace Egan
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs - Nature
Abstract Clonal haematopoiesis arises when a haematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type HSCs, resulting in its clonal expansion. Individuals with clonal haematopoiesis are at increased risk of developing haematologic neoplasms and other age-related inflammatory illnesses1,2,3,4. Suppressing the expansion of mutant HSCs may prevent these outcomes; however, such interventions have not yet been identified.
Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis - Nature Communications
Abstract The competitive advantage of mutant hematopoietic stem and progenitor cells (HSPCs) underlies clonal hematopoiesis (CH). Drivers of CH include aging and inflammation; however, how CH-mutant cells gain a selective advantage in these contexts is an unresolved question. Using a murine model of CH (Dnmt3aR878H/+), we discover that mutant HSPCs sustain elevated mitochondrial respiration which is associated with their resistance to aging-related changes in the bone marrow microenvironment.
The Arrival of the Ultimate Disillusionment: The Right to a Jury Should be Recognized in the Juvenile Court System Should be Recognized in the Juvenile Court System
Ayuda Buscar en la ayuda Buscar en la ayuda The Arrival of the Ultimate Disillusionment: The Right to a Jury Should be Recognized in the Juvenile Court System Should be Recognized in the Juvenile Court System [1] Northwestern Pritzker School of Law Localización: The journal of criminal law and criminology, ISSN 0091-4169, Vol. 2, Nº. 114, 2024, págs.
Airdrop Guide Inside
Introduction: The world of cryptocurrency is buzzing with excitement over the concept of airdrops. For those unfamiliar, airdrops are a way for cryptocurrency projects to distribute tokens to a large number of wallets in a short period. If you're looking to maximize your earnings through airdrops, especially in the realm of ReHold, this ultimate guide is tailored just for you.
How and where to vote in Albuquerque
Election Day is on Nov. 7 and knowing where and how to cast your ballot is just as important as knowing who you’re casting that ballot for. There are three major ways to vote – through an absentee ballot (also known as mail-in ballot), voting on Election Day or voting early. Absentee ballots in New Mexico require an application to state where the ballot should be sent. The last day to request an absentee ballot is Oct. 24. Past that, your civic duty must be performed in person.
Contribution of metabolic abnormalities to acute myeloid leukemia pathogenesis
Hallmarks of cancer: new dimensions. Cancer Discov. 2022; 12: 31-46 Hallmarks of cancer: the next generation. Cell. 2011; 144: 646-674 Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013; 12: 49-61 Lagadinou Eleni D. et al. BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell.
Mitochondrial and Metabolic Pathways Regulate Nuclear Gene Expression to Control Differentiation, Stem Cell Function, and Immune Response in Leukemia
Reviews Grace Egan, Dilshad H. Khan, Jong Bok Lee, Sara Mirali, Li Zhang and Aaron D. Schimmer DOI: 10.1158/2159-8290.CD-20-1227 Published May 2021 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below. Abstract Mitochondria are involved in many biological processes including cellular homeostasis, energy generation, and apoptosis.
The Kenan Institute for Ethics at Duke University
Everyone: “Hey! How was spring break?!” Me: “Uh, well I didn’t really have spring break…” Everyone: “Wait, what do you mean?” Me: “I actually just got back from Jordan. I was there for a month doing research with the local refugee population.” Everyone: “No way! That’s so cool! How was it?” Me: “Oh, you know, it was good. Learned a lot, but still processing it.” Everyone: “Of course. I want to hear all about it.
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