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Grace L. Barnes on Muck Rack

Grace L. Barnes

As seen in: Nature, American Society for Microbiology (ASM)
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Articles

Profiling IgG and IgA antibody responses during vaccination and infection in a high-risk gonorrhoea population - Nature Communications

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By Lenka Stejskal, Odile B Harrison, Ian M. Feavers, Ann E. Jerse, Grace L. Barnes, Christoph M. Tang, Eduard J Sanders, Fidel Ramirez-Bencomo, Smruti Rashmi
| Nature Verified
Abstract Development of a vaccine against gonorrhoea is a global priority, driven by the rise in antibiotic resistance. Although Neisseria gonorrhoeae (Ng) infection does not induce substantial protective immunity, highly exposed individuals may develop immunity against re-infection with the same strain. Retrospective epidemiological studies have shown that vaccines containing Neisseria meningitidis (Nm) outer membrane vesicles (OMVs) provide a degree of cross-protection against Ng infection.
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Pretomanid Pharmacokinetics in the Presence of Rifamycins: Interim Results from a Randomized Trial among Patients with Tuberculosis

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By Grace L. Barnes, Rodney Dawson, Elisa H. Ignatius, Kim Narunsky
| American Society for Microbiology (ASM)
Pharmacology Elisa H. Ignatius, Mahmoud Tareq Abdelwahab, Bronwyn Hendricks, Nikhil Gupte, Kim Narunsky, Lubbe Wiesner, Grace Barnes, Rodney Dawson, Kelly E. Dooley, Paolo Denti DOI: 10.1128/AAC.01196-20 ABSTRACT Shorter, more potent regimens are needed for tuberculosis. The nitroimidazole pretomanid was recently approved for extensively drug-resistant tuberculosis in combination with bedaquiline and linezolid.
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Factors associated with pulmonary impairment in HIV-infected South African adults

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By Akshay Gupte, Michelle Wong, Reginah Msandiwa, Grace L. Barnes
| PLOS
Median (IQR) age at enrollment was 36 (32–41) years, 85% were female and 30% ever-smoked with a median (IQR) exposure of 3 (1–6) pack-years. Median (IQR) CD4 count and viral load at enrollment were 372 (261–518) cells/mm 3 and 2655 (91–13,548) copies/mL respectively. Overall, 25% were receiving ART at enrollment, 16% of whom reported at least 6 months of ART receipt. OLD was found in 35 (5%) at enrollment.
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