Grace Whelan

LVD left ventricular dysfunction MI myocardial infarction TKI tyrosine kinase inhibitor uEVs urinary extracellular vesicles VEGFi vascular endothelial growth factor inhibitor 1 INTRODUCTION Vascular endothelial growth factor inhibitors (VEGFi) have transformed cancer therapy paradigms by effectively targeting angiogenesis, a critical process for tumour growth and metastasis (Monsky et al., 2002).

The second national lockdown announced by the prime minister on 31 October is another blow to the fashion retail sector. After a difficult year, the industry was gearing up to recoup losses over peak trading. Now fashion retailers will be forced to close for at least a month at one of the most profitable times of the year. Government data revealed that in the first lockdown, retail was one of the worst-affected sectors, and many employers placed staff on furlough.

The pre-pandemic retail property market was already under pressure as retailers tried to shrink their portfolios – and rent and rates liabilities – and adapt to an omnichannel environment. The Covid-19 lockdown on 23 March forced sudden – and some believe irreversible – change on the relationship between landlords and their retail tenants.