Articles by Grant Murphy
A Chemoenzymatic Synthesis of STING Agonist MK-2118
Cite Jump to ExpandCollapse ArticleMarch 4, 2026 A Chemoenzymatic Synthesis of STING Agonist MK-2118 Click to copy article linkArticle link copied! Chihui An* Chihui An Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States *Email: [email protected] Grant S. Murphy Grant S. Murphy Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States Jeffrey C. Moore Jeffrey C.
Enzyme purification and sustained enzyme activity for pharmaceutical biocatalysis by fusion with phase‐separating intrinsically disordered protein
1 INTRODUCTION An increasing number of enzymes have been discovered and engineered thanks to modern genomics and proteomics. This has enabled enzymes to be applied in many fields for in vitro biocatalysis, including the chemical, food, and materials industries (Ismail & Nielsen, 2010; Kannan et al., 2023; Kirk et al., 2002). In particular, biocatalysis is increasingly prominent in the pharmaceutical industry (Griengl et al., 2000; Hills, 2003; McIntosh & Benkovics, Silverman, et al., 2021).
Quantifying dermal microcirculatory changes of neuropathic and neuroischemic diabetic foot ulcers using spatial frequency domain imaging: a shade of things to come?
Emerging technologies, pharmacology and therapeutics Quantifying dermal microcirculatory changes of neuropathic and neuroischemic diabetic foot ulcers using spatial frequency domain imaging: a shade of things to come?
Role of simple descriptors and applicability domain in predicting change in protein thermostability
The melting temperature (Tm) of a protein is the temperature at which half of the protein population is in a folded state. Therefore, Tm is a measure of the thermostability of a protein. Increasing the Tm of a protein is a critical goal in biotechnology and biomedicine. However, predicting the change in melting temperature (dTm) due to mutations at a single residue is difficult because it depends on an intricate balance of forces.
A de novo enzyme catalyzes a life-sustaining reaction in Escherichia coli
Abstract Producing novel enzymes that are catalytically active in vitro and biologically functional in vivo is a key goal of synthetic biology. Here we describe Syn-F4, the first de novo protein that meets both criteria. Purified Syn-F4 hydrolyzes the siderophore ferric enterobactin, and expression of Syn-F4 allows an inviable strain of Escherichia coli to grow in iron-limited medium.
Opensource Python whitebox code analysis tool recommendations
From: Grant Murphy Date: Tue, 6 Dec 2016 10:26:14 -0800 On Tue, Dec 6, 2016 at 9:02 AM, Fiedler Roman wrote: Hello list, I just stubled over effects of following programming error due to unwanted singleton in Python, bypassing intended process restrictions (allowed number of elements in my case) and of course data corruption: class A: def __init__(self, value=[]): self.value=value self.valueCloned=value[:] def show(self): print 'IDs value %x, cloned %x' % (id(self.value),...
Faces From The Past
This campaign will receive all funds raised even if it does not reach its goal.
[OSSA 2016-002] Xen connection password leak in logs via StorageError (CVE-2015-8749)
From: Grant Murphy Date: Tue, 12 Jan 2016 10:07:25 -0800 ==================================================================== OSSA-2016-002: Xen connection password leak in logs via StorageError ==================================================================== :Date: January 11, 2016 :CVE: CVE-2015-8749 Affects ~~~~~~~ - Nova: >=2014.2 <= 2015.1.2, == 12.0.0 Description ~~~~~~~~~~~ Matt Riedemann from IBM reported an information disclosure vulnerability in Nova.
CVE request for vulnerability in OpenStack Nova
From: Grant Murphy Date: Thu, 7 Jan 2016 11:25:55 -0800 A vulnerability was discovered in OpenStack (see below). In order to ensure full traceability, we need a CVE number assigned that we can attach to further notifications. This issue is already public, although an advisory was not sent yet.
[OSSA-2015-019] Glance image status manipulation (CVE-2015-5251)
From: Grant Murphy Date: Tue, 22 Sep 2015 12:19:04 -0700 =============================================== OSSA-2015-019: Glance image status manipulation =============================================== :Date: September 22, 2015 :CVE: CVE-2015-5251 Affects ~~~~~~~ - Glance: =2015.1.0, <=2015.1.1 Description ~~~~~~~~~~~ Hemanth Makkapati of Rackspace reported a vulnerability in Glance.
[OSSA 2015-013] Glance task flow may fail to delete image from backend (CVE-2015-3289)
[OSSA 2015-013] Glance task flow may fail to delete image from backend (CVE-2015-3289) From: Grant Murphy Date: Tue, 28 Jul 2015 08:27:23 -0700 ===================================================================== OSSA-2015-013: Glance task flow may fail to delete image from backend ===================================================================== :Date: July 28, 2015 :CVE: CVE-2015-3289 Affects ~~~~~~~ - Glance: versions 2015.1.0 Description ~~~~~~~~~~~ Abhishek Kekane from NTT reported...
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