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Articles by Gray Faculty
Isozyme-Specific Inhibition of GSK-3 Reveals Distinct Cellular Responses in Huntington's Disease Fibroblasts
AJUBA LIM domain-containing protein Ajuba BNIP3 Bcl-2 interacting protein 3 CALCOCO1 calcium-binding and coiled-coil domain-containing protein 1 CatD cathepsin D DAG1 dystroglycan 1 DEPs differentially expressed proteins DEPTOR DEP domain-containing MTOR-interacting protein DRP1 dynamin-related protein-1 ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2, Autotaxin FIS1 mitochondrial fission 1 protein FKBP8 peptidyl-prolyl cis-trans isomerase FKBP8 FUNDC1 FUN14 domain-containing protein...
The hidden impact of cage position on behavioral phenotyping and reproducibility
Cage position within an animal-room rack is among the most routine housing decisions, yet it shapes both ambient illumination and husbandry contact. We asked whether this alone, in naive, untreated mice, alters adult behavior. Male and female ICR mice were housed from birth to adulthood on the uppermost or lowermost rack shelf.
Fetal Liver Volume and Morphology in Growth-Restricted Fetuses and Their Association With Neonatal Morbidity: An MRI Study
1 Introduction Fetal growth restriction (FGR) refers to a condition in which the fetus fails to achieve its genetically determined growth potential [1]. The leading cause of FGR is placental insufficiency, which limits the distribution of oxygen and nutrients to the fetal organs and often promotes redistribution of the fetal circulation to prioritize blood flow to the heart and brain [2].
The interaction between GPCR and Na + channels via G o proteins in excitable cells
Kim, S. H., Kim, J., So, I. & Lee, H. H. Direct crosstalk between GPCRs and ion channels via G proteins. Exp Mol Med. 57, 2717–2728 (2025). Article CAS Google Scholar Won, J. et al. Molecular architecture of the Gαi-bound TRPC5 ion channel. Nat comm 14, 2550 (2023). Article CAS Google Scholar Anis, Y. et al. Activation of Go-proteins by membrane depolarization traced by in situ photoaffinity labeling of galphao-proteins with [alpha32P]GTP-azidoanilide. J Biol Chem 274, 7431–7440 (1999).
Time to Move Upstream? A Framework for Expanding the Focus of Freezing of Gait to Prodromal, Subclinical, and Pre-FOG Stages
AI artificial intelligence DBS deep brain stimulation EEG electroencephalography EMG electromyography FOG freezing of gait ICFOG International Conference on Freezing of Gait MCI mild cognitive impairment ON/OFF medication states PD Parkinson's disease 1 Introduction Freezing of gait (FOG) is one of the most disabling and poorly understood motor symptoms of Parkinson's disease (PD), contributing substantially to falls, reduced mobility, and loss of independence (Walton et al. 2015; Giladi et al.
Assessing Predictive Utility of Ultrasound for Tumor Characteristics in Thyroid Cancer
1 Introduction Ultrasound (US) is the gold standard imaging modality for the evaluation of thyroid nodules and suspected malignancy. It is widely accessible, free of ionizing radiation, and provides high-resolution assessment of cervical soft tissues, thus making it the imaging of choice for thyroid assessment [1, 2].
Thermal Injury Producing Melanoma-Like Features on Reflectance Confocal Microscopy
1 Introduction Thermal injury, whether caused by heat or cold injury, can induce changes in pigmented lesions that mimic melanoma on clinical examination, dermoscopy, and reflectance confocal microscopy (RCM). Adjunctive RCM for equivocal lesions has been shown to reduce unnecessary excisions by improving specificity [1]. However, thermal injury can mimic melanoma on RCM and thereby limit its diagnostic accuracy.
RSV Disease Among Hospitalized Children: Second vs. First Year of Life Multicenter Study
CHD congenital heart disease CI confidence interval CLD chronic lung disease DS Down syndrome EMR/EMRs electronic medical record IQR interquartile range IRB Institutional Review Board LOS length of stay LRTI lower respiratory tract infection NAAT nucleic acid amplification test OR odds ratio PICU pediatric intensive care unit RSV respiratory syncytial virus RT-PCR reverse transcription polymerase chain reaction SD standard deviation SES socioeconomic status VIF variance inflation factor wGA...
PIH1D2 Loss-of-Function Directs Ciliary and Cell Cycle Defects Resulting in Left Isomerism With or Without Biliary Atresia
1 Introduction In normal human anatomy, the position and orientation of thoraco-abdominal organs and major blood vessels exhibit a distinct asymmetry along the body's left–right axis. For example, the heart, aorta, stomach and spleen are positioned on the left side, whereas the inferior vena cava, liver and gall bladder are positioned on the right side. This is referred to situs solitus [1, 2].
Wood's Lamp Reflectance by Topical 1.5% Ruxolitinib
Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study. References 1 and , “Robert Williams Wood: Pioneer of Invisible Light,” Photodermatology, Photoimmunology & Photomedicine 32, no. 2 (2016): 60–65. 2, , , et al., “Vitiligo,” Nature Reviews Disease Primers 11, no. 1 (2025): 85.
Safety and pharmacokinetic profiles of Anumigilimab: Implications for future HS and PPP trials
We live in a time of immense potential, with numerous novel treatments in the pipeline for diseases for which, just a decade ago or more, we had little to offer in our therapeutic arsenal. Moreover, researchers and clinicians continue to strive to expand our armamentarium.
Video-Based Assessment of Tonsil Size in Children With Sleep-Disordered Breathing
Conflicts of Interest The authors declare that there is no conflicts of interest and no financial or other relationship with TytoCare. The company had no role in the study design, data collection, analysis, interpretation, or manuscript preparation. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
NMN Ameliorates STXBP1-R292C Variant-mediated Developmental and Motor Dysfunction: Molecular Docking and Functional Studies
Abramov D, Guiberson NGL, Daab A, Na Y, Petsko GA, Sharma M, Burré J (2021) Targeted stabilization of Munc18-1 function via pharmacological chaperones. EMBO Mol Med 13(1):e12354.
Moving Beyond the Breslow Thickness Threshold: Can Dynamic Indices Refine Risk Assessment in Thin Melanoma?
No abstract is available for this article. Conflicts of Interest The author declares no conflicts of interest. Data Availability Statement Data sharing is not applicable to this article as no datasets were generated or analysed during the current study. References 1, , , et al., “Guidelines of Care for the Management of Primary Cutaneous Melanoma,” Journal of the American Academy of Dermatology 80 (2019): 208–250.
Tricuspid regurgitation after left-sided STEMI: an independent marker of adverse prognosis
Background Risk stratification for patients with ST-elevation myocardial infarction (STEMI) primarily focuses on left ventricular ejection fraction (LVEF) and ischemic mitral regurgitation (MR), whereas the prognostic significance of tricuspid regurgitation (TR) after left-sided STEMI remains poorly defined.
The ‘early CSP’ is not a CSP: 3D transvaginal neurosonographic study of fetal cavum septi pellucidi formation and septal development
DATA AVAILABILITY STATEMENT Research data are not shared. Supporting Information Filename Description uog70347-sup-0001-TableS1.docxWord 2007 document , 22 KB Table S1 Multivariable linear regression analysis of factors associated with visualization of cavum septi pellucidi (CSP).
Combined Incisions in Retroperitoneal Sarcoma Surgery: Safe Access Without Added Morbidity in a Single Center Retrospective Analysis
1 Introduction Retroperitoneal sarcomas are rare malignant tumors of mesenchymal origin, accounting for a minority of soft tissue sarcomas but associated with substantial morbidity and mortality [1]. Because of their retroperitoneal location and the potential for silent growth, these tumors often reach a large size before diagnosis, resulting in technically demanding resections [2, 3].
Microbial Culture Profiles Following Fetal Surgery Versus Spontaneous Preterm Prelabor Rupture of Membranes in Multifetal Gestations
1 Introduction Antenatal care for monochorionic (MC) pregnancies has undergone substantial advancements over recent decades [1, 2]. The introduction of high-resolution ultrasound and the development of fetal surgical techniques have significantly improved outcomes in these high-risk pregnancies [3, 4].
Fetal septal veins: normal finding on prenatal ultrasound
With the development of new ultrasound probes and the introduction of transvaginal neurosonography, normal and abnormal structures that would not have been visualized previously become evident. This may lead to an increased risk of referrals for suspected abnormal findings that, in time, will be recognized as normal variants of no clinical significance when isolated1.
HLA profiles in immune checkpoint inhibitor-associated neuromuscular adverse events
Abstract Background and objectives: Immune checkpoint inhibitors (ICIs) can cause neuromuscular adverse events (nmAEs), yet the immunogenetic background of affected patients remains poorly characterized. We descriptively characterized the HLA profile of patients with ICI-associated nmAEs at two tertiary Israeli centers and explored allele and multilocus allele patterns relative to available population references.
From Isolated to Complex: Diagnostic Yield of Chromosomal Microarray and Exome Sequencing in Fetal Growth Restriction
1 Introduction Fetal growth restriction (FGR), defined by an estimated fetal weight below the 10th percentile with or without abnormal Doppler indices, affects 5%–10% of pregnancies and is a leading cause of perinatal morbidity and mortality [1, 2], including an increased risk of neurodevelopmental delay [3].
Liver Transplantation in Inborn Errors of Metabolism: A Retrospective Study of a National Experience
Orith Waisbourd-Zinman and Yuval E. Landau contributed equally to the work. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1 and , Inborn Metabolic Diseases: Diagnosis and Treatment (Springer Nature, 2022), 14–22.
An Epidemiology-Constrained Framework for Mechanistic Hypothesis Restriction and Prioritization in Complex Disease
1 Introduction Despite unprecedented advances in molecular biology, many chronic diseases remain mechanistically unresolved. We use the term complex chronic disease to describe chronic disorders characterised by prolonged or heterogeneous disease trajectories, multiscale interactions among genetic, environmental, developmental and biological processes, limited experimental accessibility to initiating events, phenotypic heterogeneity and reproducible population-level structure.
Low-titer O whole-blood transfusion for life-threatening gastrointestinal and post-partum hemorrhage
CONFLICT OF INTEREST STATEMENT M.Y. is on the scientific advisory board for Hemanext, consults for Legacy Innovations, has given paid lectures for Terumo BCT and Grifols, and owns equity in Velico Medical, Inc. P.C.S. is a co-founder and CMO for Kalocyte, consults for Cerus, Rafa, and Grifols, and is on the advisory board for Haima. The other authors declare no conflicts of interest.
Flow Cytometry-Guided Diagnosis of Cortical T-Lymphoblastic Lymphoma Presenting With a Massive Mediastinal Mass and Borderline Bone Marrow Involvement
1 Introduction T-cell lymphoblastic lymphoma (T-LBL) is a highly aggressive neoplasm derived from immature thymic T-cell precursors and represents the tissue-based counterpart of T-cell acute lymphoblastic leukemia (T-ALL) [1, 2]. The distinction between these entities is largely determined by the extent of bone marrow involvement, with significant marrow infiltration supporting T-ALL [1, 2].
Real-world safety of concomitant colchicine and statin therapy
Supporting Information Filename Description acr80172-sup-0001-Disclosureform.pdfPDF document, 538.2 KB Data S1: Disclosureform acr80172-sup-0002-Supinfo.docxWord 2007 document , 101.9 KB Data S2: Supinfo
Evolving patterns of hepato-pancreato-biliary surgery in the immunotherapy era
Abstract Introduction: Immunotherapy has revolutionized cancer treatment with remarkable outcomes, expanding treatment options and enabling new surgical opportunities for patients with previously unresectable disease. This descriptive study examines the impact of immunotherapy on the volume and nature of hepato-pancreato-biliary (HPB) surgeries in a large referral center and reviews the current literature.
Biphasic Clinical Course of Pediatric Cytomegalovirus-Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long-Term Outcomes
ALT alanine aminotransferase ANA antinuclear antibodies ANC absolute neutrophil count AST aspartate aminotransferase CI confidence interval CMV cytomegalovirus DAT direct antiglobulin test IQR interquartile range ITP immune thrombocytopenia PCR polymerase chain reaction 1 Introduction Immune thrombocytopenia (ITP) is the most frequently encountered immune-mediated cytopenia [1].
Large language models as judges for clinical generative AI evaluation
Scalable evaluation of free-form clinical generative AI outputs remains a major barrier to safe deployment. While LLM-as-a-Judge frameworks offer a potential alternative to manual review, most evidence comes from benchmarks, documentation, or other constrained settings.
Eyeballing for Frailty Assessment in Elderly Patients Referred for Coronary Angiography
Disclosure No sponsor had any role in the study design, data collection, data analysis, data interpretation, or manuscript preparation. Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jgs70713-sup-0001-Supplementary_Figure.pdfPDF document, 155.3 KB Figure S1: Receiver operating characteristic (ROC) curve analysis stratified by sex. Figure S2: Receiver operating characteristic (ROC) curve analysis stratified by admission status.
Antibiotic-Refractory Chronic Pouchitis After Ileal Pouch-Anal Anastomosis: Current and Emerging Therapeutic Strategies
Le Berre C, Honap S, Peyrin-Biroulet L. Ulcerative colitis. Lancet. 2023;402(10401):571–84. Article PubMed Google Scholar Tsai L, Ma C, Dulai PS, Prokop LJ, Eisenstein S, Ramamoorthy SL, et al. Contemporary risk of surgery in patients with ulcerative colitis and Crohn’s disease: a meta-analysis of population-based cohorts. Clin Gastroenterol Hepatol. 2021;19(10):2031-45 e11. Article PubMed Google Scholar Dai N, Haidar O, Askari A, Segal JP.
Global Recommendations for the Use of Diagnostic Genomic Sequencing in the Prenatal Setting on Behalf of the ESHG and ISPD
1 Introduction Diagnostic genomic sequencing is increasingly being implemented in the prenatal setting for fetuses with structural anomalies identified by imaging. Such testing provides information for multiple purposes that is, guiding treatment decisions, preparation for the birth of an affected child or termination of a pregnancy. Some national committee's statements have been published [1].
A Germline Missense Variant in the NSDHL Gene Underlies Inflammatory Linear Verrucous Epidermal Nevus
1 Introduction Inflammatory linear verrucous epidermal nevus (ILVEN) represents a benign condition characterized by pruritic erythematous papules and plaques distributed along the lines of Blaschko [1]. It typically manifests either congenitally or within the first years of life, gradually progresses over months to years with stabilization at late childhood [1].
Diagnostic Yield of Brain MRI in Pediatric Short Stature: Hypothalamic–Pituitary Lesions and Incidental Findings in Real-World Practice
1 Introduction Short stature in children is a common clinical presentation with diverse etiologies, including genetic syndromes, systemic diseases, endocrine disorders, and idiopathic causes [1]. As part of standard evaluation, children with short stature often undergo an endocrine workup to exclude growth hormone deficiency (GHD), which affects approximately 1 in 3000–9000 children [2]. Initial assessment typically includes serum IGF-1 levels, followed by provocative GH stimulation tests.
Long-Term Quality of Life After Removal of Batteries and Magnets From the Nose in Children
1 Introduction Insertion of foreign objects (FOs) into the nasal cavities of children is a well-documented concern in pediatric otolaryngology. Button batteries are often viewed as medical emergencies due to their potential for severe complications, including mucosal damage, septal perforation, and chemical burns [1-3]. Magnets may also cause the same risk when it is inserted into both nostrils, potentially causing tissue necrosis from sustained compression to the nasal septum [1].
Long-term outcomes and patterns of failure in patients with thymic malignancies treated with surgery and radiation therapy
INTRODUCTION Thymic epithelial tumors are rare but represent the most common primary tumors of the anterior mediastinum in adults.1 The overall incidence of thymoma is on the order of 0.13–0.17 cases per 100,000 person-years, reflecting its rarity.2, 3 Thymomas are typically indolent, slow-growing tumors that spread by local extension; metastases usually remain confined to intrathoracic sites, such as the pleura, pericardium, or lung parenchyma, and extrathoracic dissemination is uncommon.
Safety and Effectiveness of a High-Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis
aPTT activated partial thromboplastin time AUC area under the curve CDT catheter-directed thrombolysis FFP fresh frozen plasma IQR interquartile range IVC inferior vena cava PCICU pediatric cardiac intensive care unit PT prothrombin time RBC red blood cells/red blood cell transfusion SVC superior vena cava TAPVR total anomalous pulmonary venous return TE thromboembolism tPA tissue plasminogen activator 1 Introduction The incidence of pediatric thromboembolism (TE) has increased significantly...
Midlife BMI and A Body Shape Index in relation to mortality and coronary heart disease events in a nationwide cohort
Abstract Background: Obesity is a known cardiovascular risk factor. A Body Shape Index (ABSI) is a waist circumference (WC)-based measure of abdominal obesity, independent of Body Mass Index (BMI). We examined the independent and joint associations of ABSI and BMI with long-term mortality and coronary heart disease (CHD) events among initially young to middle-aged adults.
The Effect of LRRK2 and GBA1 Mutations on Survival in Early- and Late-Onset Parkinson's Disease
Patients living with Parkinson's disease (PD) face increased mortality compared to the general population, with a recent meta-analysis showing a 62% higher risk for all-cause mortality.1 Better understanding of the disease process and expected outcomes is important for patients and caregivers.
Robotic Surgery in Australasian Gynaecology: Results of a 2025 Cross-Sectional Survey
1 Introduction Robotic-assisted surgery has become an increasingly available option in minimally invasive gynaecology, although adoption rates and perceived clinical value remain highly variable across healthcare systems [1, 2].
EP05.29: Prenatal phenotype and outcomes of agenesis of the ductus venosus with and without umbilical portosystemic venous shunt: single-center cohort
No abstract is available for this article. Related Information Check for updates Issue Online: 31 August 2026 Version of Record online: 31 August 2026 Manuscript accepted: 06 July 2026 Scite uses AI to classify citations by whether they support, contradict, or merely mention the referenced claims.
SGLT2 inhibitor use is associated with more polycythemia vera diagnosis codes but not with JAK2 -positive polycythemia vera: a propensity score–matched cohort study
Abstract Background: Treatment with sodium-glucose cotransporter 2 inhibitors (SGLT2is) is associated with modest increases in hematocrit, which may prompt hematologic evaluation. We examined whether SGLT2i use is associated with increased detection of previously unrecognized myeloproliferative neoplasms (MPNs) and compared diagnosis code–based with JAK2-positive ascertainment of polycythemia vera (PV).
Association between time from cancer diagnosis to surgery for femoral metastasis and overall survival among patients with malignancy
Get full text access Log in, subscribe or purchase for full access. References: 1. Guzik, G. Oncological and functional results after surgical treatment of bone metastases at the proximal femur BMC surgery. 2018; 18:1-8 2. Hansen, B. ... The Scandinavian Sarcoma Group skeletal metastasis register survival after surgery for bone metastases in the pelvis and extremities Acta Orthopaedica Scandinavica. 2004; 75(sup311):11-15 3. Böhm, P. ∙ Huber, J.
Natural History of PI-RADS 3 Lesions on Serial Prostate mpMRI
1 Introduction Multiparametric MRI (mpMRI) has become central to prostate cancer evaluation, improving detection of significant tumors while reducing unnecessary biopsies [1, 2]. However, the indeterminate PI-RADS (Prostate Imaging Reporting and Data System) 3 category remains a management dilemma. PI-RADS 3 lesions are common (typically apparent in 20%–30% of scans) and carry a non-negligible cancer risk, but most underlying cancers are low-risk. For example, Schoots et al.
Beyond Histamine: Mast Cell-Neuron Communication in Chronic Pruritic and Pain Disorders
1 Introduction Chronic pruritus and pain are debilitating sensory disorders traditionally viewed through a histamine-centric framework, in which mast cells trigger symptoms via histamine release and activation of sensory neurons [1]. This model, exemplified by urticaria, positioned antihistamines as first-line therapy. However, more chronic pruritic and pain disorders respond poorly to antihistamines, indicating that histamine plays a limited role in persistent disease [2, 3].
HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function
Open figure viewer Hepatocyte growth factor (HGF) is a pleiotropic growth factor that signals through the receptor tyrosine kinase c-Met and regulates epithelial growth, morphogenesis, and survival in multiple organs, including the pancreas (1,2). In the endocrine pancreas, c-Met signaling regulates β-cell function. It enhances their resilience to metabolic and inflammatory stress, positioning the HGF/c-Met axis as a key pathway shaping glucose homeostasis in health and diabetes (2–6).
Beyond the Transplant: Chronic Kidney Disease in Pediatric Hematopoietic Stem Cell Transplant Survivors-A 20-Year Single-Center Cohort Study
AKI acute kidney injury CKD chronic kidney disease CKiD chronic kidney disease in children (eGFR formula) eGFR estimated glomerular filtration rate EMR electronic medical record GVHD graft-versus-host disease HSCT hematopoietic stem cell transplantation IQR interquartile range KDIGO Kidney Disease: Improving Global Outcomes SCMCI Schneider Children's Medical Center Israel SD standard deviation TMA thrombotic microangiopathy 1 Introduction Hematopoietic stem cell transplantation (HSCT) is a...
Real-World Outcomes of Venetoclax-Based Therapy in Treatment-Naïve and Relapsed/Refractory CLL/SLL: Interim Results From the Prospective REVEAL Study
Dear Editor, Venetoclax-based regimens have transformed the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with pivotal trials such as CLL13, CLL14, and MURANO demonstrating superior progression-free survival (PFS), high rates of undetectable minimal residual disease (uMRD), and the feasibility of fixed-duration therapy [1-6].
A novel glyco-inflammatory healing index for risk prediction after isolated coronary artery bypass grafting: a multicenter retrospective cohort study
Background The Glyco-Inflammatory Healing Index (GIHI), calculated as HbA1c × C-reactive protein / albumin, integrates measures of glycemic control, systemic inflammation, and nutritional status. Its association with postoperative outcomes after isolated coronary artery bypass grafting (CABG) has not been fully established, particularly according to diabetes status.
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