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The first hallmark of Alzheimer’s disease (AD) is memory loss. While spatial memory deficits are commonly reported (Lithfous et al. 2013; Parizkova et al. 2020), studies also highlight associative memory dysfunctions at the early stages of this degenerative disease (Sperling 2007). Late onset AD has a genetic component, with the APOE polymorphism currently corresponding to the most important genetic risk factor.
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Discussion The current meta-analysis included 21 articles and explored the effect of CECT on working memory in older adults. The results support efficacy of CECT on working memory as compared to those receiving no intervention and the effect is modulated by the frequency of intervention and cognitive status. The results indicate that there is a significant benefit of CECT on working memory in the elderly compared to no intervention.
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