Grazisa Rossetti

Introduction Tonsillectomy, i.e. the removal of the palatine tonsils, still is one of the most frequent surgical procedures (1). The highest prevalence of tonsillectomies is seen in the age group of less than 18 years (2) and decreases with higher age (3). Most of these surgeries are indicated to treat tonsil hyperplasia, recurrent acute tonsillitis, or a peritonsillar abscess (2).

Introduction Sepsis is recognized as a complex syndrome and defined as the dysfunctional host response to infection. It has been found to afflict 49 million people annually with 11 million deaths (19.7% of all deaths in 2017) and is the cause of most deaths from severe Covid infections (1, 2).

Introduction Recent improvements in single cell technologies led to a multitude of singe cell RNA-sequencing (scRNA-seq) studies to understand the complex interplay of immune cells in human tissues (1). The procedures to assign cell types to single cells in such data are a critical factor for the success of such studies (2). There are hardly any ‘golden rules’ or generally accepted computational workflows for assigning cell type labels to cells.