Grefachew Workalemahu on Muck Rack

Grefachew Workalemahu

As seen in: The Journal of Immunology, Gastrointestinal Endoscopy
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Articles

Sa1901 THE EFFICACY OF ENDOSCOPIC ULTRASOUND GUIDED BIOPSIES TO SUCCESSFULLY GENERATE PATIENT DERIVED DOWNSTREAM PDAC MODELS FROM A SINGLE PROCEDURE

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By Igor Dolgalev, Vishnu Jayaprakash, Grefachew Workalemahu, Stefani Shoreibah, Emil Agarunov, Peter Yu, Anirban Maitra, Tamas A. Gonda, Stephen C. Muzyka, Marcus Yang, Yasmine Chinda, Cody Stender, Madelyn Zamelis, Ariana Aghaaliandastjerdi
| Gastrointestinal Endoscopy
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Optimizing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through zoledronate pulse stimulation

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By Craig T Morita, Grefachew Workalemahu, Yoshimasa Tanaka
| The Journal of Immunology
Human γδ T cells expressing Vγ2Vδ2 TCRs monitor foreign- and self-prenyl pyrophosphate metabolites in isoprenoid biosynthesis to mediate immunity to microbes and tumors. Vγ2Vδ2 cells have been used for adoptive cancer immunotherapy with some partial and complete remissions. Most trials have used continuous zoledronate exposure to expand Vγ2Vδ2 cells. Zoledronate inhibits farnesyl pyrophosphate synthase causing isopentenyl pyrophosphate to accumulate that then stimulates Vγ2Vδ2 cells.
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