Gregorie Stik on Muck Rack

Gregorie Stik

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Articles

Replication-stress-induced chromatin loops protect fork stability

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By Vincent Gaggioli, Kaustav Sengupta, Ashutosh Roy Choudhury, Joanna Paulson, Raviprasad Kuthethur, Alex Whale, Jeroen van den Berg, Iván Galván-Femenía, Eleni Maria Manolika, Hina Khan, Alexander van Oudenaarden, Argyris Papantonis, Jonathan Houseley, Sriram Sridharan, Arnab Ray Chaudhuri, Aleix Bayona-Feliu, Nitika Taneja, Collin Bakker, Calvin S. Y. Lo, Leire Asua Intxausti, Noelia Gil-Lanza, Sangavi Eswaran, Estel Ferré, Gregorie Stik
| Nature Verified
Abstract Replication stress poses a major threat to genome integrity, yet how higher-order chromatin organization contributes to replication fork protection remains unclear1,2. Here we show that replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks3.
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